(1aS,2aR,65,95, 10S,11R,21E,24aR,24b5)-6-tert-butyl-15-ch10ro-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-10-methyl-4,7,18-trioxo-1a,2,2a,4,5,6,7,10,11,20,23,24,24a,24b-tetradecahydro-1H,9H,18H-8,11-methanocyclopropa[4’,5’]cyclopenta[1’,2’:18,19][1,10,3,6,12]dioxatriazacyclononadecino[11,12-b]quinazoline-9-carboxamide | 1535215-22-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1aS,2aR,65,95, 10S,11R,21E,24aR,24b5)-6-tert-butyl-15-ch10ro-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-10-methyl-4,7,18-trioxo-1a,2,2a,4,5,6,7,10,11,20,23,24,24a,24b-tetradecahydro-1H,9H,18H-8,11-methanocyclopropa[4’,5’]cyclopenta[1’,2’:18,19][1,10,3,6,12]dioxatriazacyclononadecino[11,12-b]quinazoline-9-carboxamide
• 英文别名: (1R,14E,18R,19S,21S,23R,27S,30S,31S)-27-tert-butyl-7-chloro-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonylcarbamoyl]cyclopropyl]-31-methyl-11,25,28-trioxo-2,24-dioxa-4,12,26,29-tetrazahexacyclo[27.2.1.03,12.05,10.018,23.019,21]dotriaconta-3,5(10),6,8,14-pentaene-30-carboxamide
• CAS: 1535215-22-5
• 化学式: C₄₁H₅₁ClF₂N₆O₉S
• 分子量: 877.407
• InChiKey: IGUHCZBLHPXJGQ-KIIFNKTMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  60
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.66
• 拓扑面积：
  201
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• Inhibitors of hepatitis C virus
  申请人：Gilead Pharmasset LLC

  公开号：US10335409B2

  公开（公告）日：2019-07-02

  Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.

  公开了式 I 的化合物 及其药学上可接受的盐类。还公开了使用所述化合物的方法和含有所述化合物的药物组合物。
• INHIBITORS OF HEPATITIS C VIRUS
  申请人：Gilead Sciences, Inc.

  公开号：US20160361375A1

  公开（公告）日：2016-12-15

  Compounds of Formula I are disclosed As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
• US9655944B2
  申请人：——

  公开号：US9655944B2

  公开（公告）日：2017-05-23