6-methyl-4-(trifluoromethyl)picolinic acid | 1256818-05-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-methyl-4-(trifluoromethyl)picolinic acid
• 英文别名: 6-Methyl-4-(trifluoromethyl)pyridine-2-carboxylic acid
• CAS: 1256818-05-9
• 化学式: C₈H₆F₃NO₂
• 分子量: 205.136
• InChiKey: YCWCFDBJXWABJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  6-methyl-4-(trifluoromethyl)picolinic acid 在 盐酸羟胺 、 ammonium acetate 、 sodium acetate 、 三乙胺 、 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 、 锌 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 乙醇 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 81.0h， 生成 1-(3-chloro-4-fluorophenyl)-1-methyl-3-((6-methyl-4-(trifluoromethyl)pyridin-2-yl)(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)methyl)urea
  参考文献：
  名称：

  [EN] HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
  [FR] COMPOSÉ HÉTÉROCYCLIQUE, COMPOSITION PHARMACEUTIQUE ET UTILISATION ASSOCIÉE

  摘要：

  Disclosed a heterocyclic compound, a pharmaceutical composition and a use thereof. Provided a compound represented by formula I, a solvate thereof, a pharmaceutically acceptable salt thereof or a solvate of the pharmaceutically acceptable salt thereof. The compound shows a good inhibitory effect on Polθ, which can be used as Polθ inhibitor to treat cancers containing DNA repair defects, such as breast, lung, and ovarian cancers.

  公开号：

  WO2023217095A1
• 作为产物：
  描述：

  6-methyl-4-(trifluoromethyl)picolinonitrile 在 乙醇 、 sodium hydroxide 作用下， 以85 %的产率得到6-methyl-4-(trifluoromethyl)picolinic acid
  参考文献：
  名称：

  [EN] HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF
  [FR] COMPOSÉ HÉTÉROCYCLIQUE, COMPOSITION PHARMACEUTIQUE ET UTILISATION ASSOCIÉE

  摘要：

  Disclosed a heterocyclic compound, a pharmaceutical composition and a use thereof. Provided a compound represented by formula I, a solvate thereof, a pharmaceutically acceptable salt thereof or a solvate of the pharmaceutically acceptable salt thereof. The compound shows a good inhibitory effect on Polθ, which can be used as Polθ inhibitor to treat cancers containing DNA repair defects, such as breast, lung, and ovarian cancers.

  公开号：

  WO2023217095A1

文献信息

• [EN] 6-SUBSTITUTED-9H-PURINE DERIVATIVES AND RELATED USES<br/>[FR] DÉRIVÉS DE 9H-PURINE SUBSTITUÉS EN POSITION 6 ET UTILISATIONS ASSOCIÉES
  申请人：BLACK DIAMOND THERAPEUTICS INC

  公开号：WO2022178256A1

  公开（公告）日：2022-08-25

  The present disclosure relates compounds of Formula (I'): and pharmaceutically acceptable salts and stereoisomers thereof. The present disclosure also relates to methods of preparing the compounds, compositions comprising the compounds, and methods of using the compounds, e.g., in the treatment of cancer.

  本公开涉及公式（I'）化合物及其药学上可接受的盐和立体异构体。本公开还涉及制备该化合物的方法，包含该化合物的组合物，以及使用该化合物的方法，例如在癌症治疗中的应用。
• Near infrared radiation-absorbing composition, near infrared radiation cut-off filter and production method therefor, and camera module and production method therefor
  申请人：FUJIFILM Corporation

  公开号：US10184052B2

  公开（公告）日：2019-01-22

  An object of the present invention is to provide a near infrared radiation-absorbing composition having favorable shielding properties in a near infrared range when used to produce cured films, a near infrared radiation cut-off filter and a production method therefor, and a camera module and a production method therefor. The near infrared radiation-absorbing composition including a copper complex formed by reacting a compound (A) having two or more coordinating atoms that form bonds using unshared electron pairs with a copper component.

  本发明的目的是提供一种在用于生产固化薄膜时在近红外范围内具有良好屏蔽性能的近红外辐射吸收组合物、一种近红外辐射截止滤光片及其生产方法，以及一种相机模组及其生产方法。近红外辐射吸收组合物包括铜络合物，该铜络合物是由具有两个或两个以上配位原子的化合物（A）与铜成分反应形成的，该化合物具有两个或两个以上配位原子，这些配位原子利用未共享电子对形成键。
• NEAR INFRARED RADIATION-ABSORBING COMPOSITION, NEAR INFRARED RADIATION CUT-OFF FILTER AND PRODUCTION METHOD THEREFOR, AND CAMERA MODULE AND PRODUCTION METHOD THEREFOR
  申请人：FUJIFILM Corporation

  公开号：US20160304730A1

  公开（公告）日：2016-10-20

  An object of the present invention is to provide a near infrared radiation-absorbing composition having favorable shielding properties in a near infrared range when used to produce cured films, a near infrared radiation cut-off filter and a production method therefor, and a camera module and a production method therefor. The near infrared radiation-absorbing composition including a copper complex formed by reacting a compound (A) having two or more coordinating atoms that form bonds using unshared electron pairs with a copper component.
• NEAR INFRARED RAY ABSORBENT COMPOSITION, NEAR INFRARED RAY CUT FILTER, SOLID IMAGE PICKUP ELEMENT, AND CAMERA MODULE
  申请人：FUJIFILM Corporation

  公开号：US20170227690A1

  公开（公告）日：2017-08-10

  Provided are a near infrared ray absorbent composition which can form a cured film having excellent near infrared ray shielding properties, a near infrared ray cut filter, a manufacturing method of a near infrared ray cut filter, a solid image pickup element, and a camera module. The near infrared ray absorbent composition includes a copper complex that is other than a copper phthalocyanine complex and has a maximum absorption wavelength in a wavelength range of 700 to 1,200 nm and in which a molar light absorption coefficient at the maximum absorption wavelength is greater than or equal to 100 (L/mol·cm).
• NEAR INFRARED ABSORBING COMPOSITION, NEAR INFRARED CUT FILTER, METHOD OF MANUFACTURING NEAR INFRARED CUT FILTER, DEVICE, METHOD OF MANUFACTURING COPPER-CONTAINING POLYMER, AND COPPER-CONTAINING POLYMER
  申请人：FUJIFILM Corporation

  公开号：US20180094086A1

  公开（公告）日：2018-04-05

  The near infrared absorbing composition includes: a copper-containing polymer having a copper complex site at a polymer side chain; and a solvent, in which the copper complex site includes a site multidentate-coordinated to a copper atom and at least one selected from the group consisting of a site monodentate-coordinated to a copper atom and a counter ion to a copper complex skeleton, and a polymer main chain and a copper atom at the copper complex site are bonded to each other through the site monodentate-coordinated to a copper atom or the counter ion.