| 169470-79-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• CAS: 169470-79-5
• 化学式: C₇H₈F₆O₈S₂
• 分子量: 398.258
• InChiKey: CIOUCOCXJOYAIB-WHFBIAKZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.46
• 重原子数：
  23.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  105.2
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  、 6-甲基-2,2′-二吡啶 在 lithium diisopropyl amide 作用下， 生成 (3S,4S)-1,6-bis(2,2'-bipyridyl-6-yl)-3,4-O-methylene-3,4-dihydroxyhexane
  参考文献：
  名称：

  A novel synthesis of optically active C2-symmetric pyridine derivatives. Efficient reaction of chiral triflates with 2-picolyllithium reagents

  摘要：

  A variety of optically active CZ-symmetric pyridine derivatives have been prepared from L- or D-tartaric acid as a chiral source via efficient coupling reactions of triflates with 2-picolyllithium reagents, and the utility of 17 and 18 as chiral ligands in the catalytic enantioselective addition of diethylzinc to benzaldehyde has been demonstrated (up to 41% ee). The synthetic procedure for the corresponding meso-isomer was also described.

  DOI：

  10.1016/0957-4166(95)00142-c
• 作为产物：
  描述：

  dimethyl 2,3-O-methylene-L-tartrate 在 吡啶 、 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  A novel synthesis of optically active C2-symmetric pyridine derivatives. Efficient reaction of chiral triflates with 2-picolyllithium reagents

  摘要：

  A variety of optically active CZ-symmetric pyridine derivatives have been prepared from L- or D-tartaric acid as a chiral source via efficient coupling reactions of triflates with 2-picolyllithium reagents, and the utility of 17 and 18 as chiral ligands in the catalytic enantioselective addition of diethylzinc to benzaldehyde has been demonstrated (up to 41% ee). The synthetic procedure for the corresponding meso-isomer was also described.

  DOI：

  10.1016/0957-4166(95)00142-c