4-二乙基氨基苯甲腈 | 2873-90-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-二乙基氨基苯甲腈
• 中文别名: 4-二乙氨基苯甲腈
• 英文名称: N,N-diethyl-4-cyanoaniline
• 英文别名: 4-diethylaminobenzonitrile；4-(diethylamino)benzonitrile；N,N-diethyl-p-cyanoaniline；4-diethylamino-benzonitrile；4-Diaethylamino-benzonitril
• CAS: 2873-90-7
• 化学式: C₁₁H₁₄N₂
• mdl: MFCD00019754
• 分子量: 174.246
• InChiKey: KMLGFOAKCYHXCQ-UHFFFAOYSA-N

物化性质

• 熔点：
  66-67°C
• 溶解度：
  溶于甲醇
• 最大波长(λmax)：
  465nm(EtOH)(lit.)
• 稳定性/保质期：
  遵照规定使用和储存，则不会发生分解。

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 危险等级：
  6.1
• 安全说明：
  S22,S36/37
• 危险类别码：
  R20/21/22
• 海关编码：
  2926909090
• 包装等级：
  III
• 危险类别：
  6.1
• 危险品运输编号：
  UN 3276

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-(Diethylamino)benzonitrile
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H331: Toxic if inhaled
H302: Harmful if swallowed
H312: Harmful in contact with skin
P261: Avoid breathing dust/fume/gas/mist/vapours/spray
P280: Wear protective gloves/protective clothing/eye protection/face protection
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P311: Call a POISON CENTER or doctor/physician
P405: Store locked up

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Section 3. Composition/information on ingredients.
Ingredient name: 4-(Diethylamino)benzonitrile
CAS number: 2873-90-7

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage: Store in closed vessels.

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Not specified
Appearance:
Boiling point: No data
Melting point: No data
Flash point: No data
Density: No data
Molecular formula: C11H14N2
Molecular weight: 174.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
UN Number: UN3439 Class: 6.1 Packing group: III
Proper shipping name: NITRILES, TOXIC, SOLID, N.O.S. (4-(Diethylamino)benzonitrile)

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  4-二乙基氨基苯甲腈 在 甲醇 、 tetraphosphorus decasulfide 作用下， 反应 72.0h， 以70%的产率得到4-(diethylamino)benzothioamide
  参考文献：
  名称：

  [EN] 2-ARYL- AND 2-HETEROARYLTHIAZOLYL COMPOUNDS, METHODS FOR THEIR PREPARATION AND USE THEREOF
  [FR] COMPOSÉS DE 2-ARYL- ET DE 2-HÉTÉROARYL-THIAZOLYLE, LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION

  摘要：

  本发明揭示了融合的双环2-芳基或2-杂环芳基噻唑基化合物及其药用盐和酯，这些化合物对抑制癌细胞的生长、特别是抑制人类乳腺癌肿瘤的生长以及治疗与分泌蛋白相关的疾病或紊乱，包括高水平的分泌蛋白水平具有用处。

  公开号：

  WO2009120826A1
• 作为产物：
  描述：

  4-(N,N-diethylamino)benzaldoxime 在 Cp*Fe(1,2-PCy₂C₆H₄O) 作用下， 以 甲苯 为溶剂， 反应 1.0h， 以94%的产率得到4-二乙基氨基苯甲腈
  参考文献：
  名称：

  仿生铁催化醛肟脱水为腈：一种通用的 N-O 氧化还原裂解方法

  摘要：

  受操作生物催化醛肟脱水的 OxdA 的启发，我们开发了一种高效的铁催化剂 Cp*Fe(1,2-Cy 2 PC 6 H 4 O) ( 1 )，它可以将各种脂肪族和芳香族醛肟快速转化为腈，同时释放H 2 O 在室温下。催化涉及通过 1e 对 N-O 键的氧化还原活化-从铁催化剂转移到肟。这种氧化还原介导的 N-O 裂解通过从酮肟底物的反应中分离出亚氨基亚铁中间体来证明。这种铁催化的无受体脱水方法代表了制备腈的一般方法，它还通过催化 Kemp 消除反应提供水杨腈。

  DOI：

  10.1021/acs.joc.2c01122

文献信息

• [EN] HEPATITIS C VIRUS INHIBITORS<br/>[FR] INHIBITEURS DU VIRUS DE L'HEPATITE C
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2003099274A1

  公开（公告）日：2003-12-04

  Hepatitis C virus inhibitors are disclosed having the general formula:(I) wherein R1, R2, R3, R', B, Y and X are described in the description. Compositions comprising the compounds and methods for using the compounds toinhibit HCV are also disclosed.

  丙型肝炎病毒抑制剂公开了具有以下通式：其中R1、R2、R3、R'、B、Y和X在描述中有所描述。还公开了包含该化合物的组合物以及使用该化合物抑制HCV的方法。
• Perfluoroalkanosulfonyl fluoride: A useful reagent for dehydration of aldoximes to nitriles
  作者：Zhao-Hua Yan、Huan Tian、Dong-Dong Zhao、Hong-Ai Jin、Wei-Sheng Tian

  DOI：10.1016/j.cclet.2015.11.004

  日期：2016.1

  Abstract The reaction of a variety of aldoximes with perfluoroalkanosulfonyl fluoride in the presence of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in dichloromethane smoothly generated the corresponding nitriles in 70%–95% yields.

  摘要在二氯甲烷中存在1,8-二氮杂双环[5.4.0] undec-7-ene（DBU）的情况下，各种醛肟与全氟链烷磺酰氟的反应均能以70％–95％的收率平稳地生成相应的腈。
• A Catalyst-Free Amination of Functional Organolithium Reagents by Flow Chemistry
  作者：Heejin Kim、Yuya Yonekura、Jun-ichi Yoshida

  DOI：10.1002/anie.201713031

  日期：2018.4.3

  of functional organolithium intermediates with well‐designed aminating reagents under mild reaction conditions using flow microreactors. The aminating reagents were optimized to achieve efficient C−N bond formation without using any catalyst. The electrophilic amination reactions of functionalized aryllithiums were successfully conducted under mild reaction conditions, within 1 minute, by using flow

  报告的是在温和的反应条件下，使用流动微反应器，通过精心设计的胺化试剂，对功能性有机锂中间体进行了亲电胺化反应。胺化试剂经过优化，可在不使用任何催化剂的情况下实现有效的CN键形成。通过使用流动微反应器，在温和的反应条件下，在1分钟内成功进行了官能化芳基锂的亲电子胺化反应。胺化试剂也通过流动方法制备。根据停止流NMR分析，快速优化了制备胺化试剂的反应时间，而无需进行后处理。集成的单流合成，包括芳基锂的生成，胺化试剂的制备，
• (<i>t</i>-Bu)₂PNP(<i>i</i>-BuNCH₂CH₂)₃N:  New Efficient Ligand for Palladium-Catalyzed C−N Couplings of Aryl and Heteroaryl Bromides and Chlorides and for Vinyl Bromides at Room Temperature
  作者：Ch. Venkat Reddy、Jesudoss V. Kingston、John G. Verkade

  DOI：10.1021/jo702367k

  日期：2008.4.1

  chlorides possessing base-sensitive substituents (nitro, ester, and keto) provide coupling products with bulky aryl amines in good to excellent yields. Aryl halides possessing other functional groups including cyano, amino, trifluoromethyl, and phenol, coupled with equal ease, producing highly functionalized amines in good to excellent yields. Moreover, an aryl chloro group can be preserved in the presence

  通过使用Pd（OAc）2，Cs 2 CO 3或NaOH，以及新的配体（t -Bu）2 PN P（i-BuNCH 2 CH 2）3 N（3a），具有碱敏感取代基（硝基，酯和酮）的电子形式多样的芳基溴化物和氯化物阵列，可提供丰满的芳基胺类化合物，并具有良好的收率和优异的收率。具有其他官能团（包括氰基，氨基，三氟甲基和苯酚）的芳基卤化物同等容易地偶联，从而以良好或优异的收率生产出高度官能化的胺。此外，在我们的反应条件下，在溴取代基的存在下可以保留芳基氯基。中银保护的胺类也有效参与。杂环溴化物和氯化物与胺进行干净的偶联，收率很高。我们协议的一个重要优势是使用了比以前报道的钯含量更低的钯含量，同时又不影响产量。空气稳定的钯络合物（η3-肉桂基）PdCl·（3a）（5）也成功地用于C-N偶联反应中，而巴豆基类似物的疗效较差。在图3a /钯（OAC）2催化剂体系促进，对于第一次，与各种胺，以产生亚胺和烯胺的乙烯基溴化物的有效耦合室温。
• Discovery and SAR of novel Naphthyridines as potent inhibitors of spleen tyrosine kinase (SYK)
  作者：Charles L Cywin、Bao-Ping Zhao、Daniel W McNeil、Matt Hrapchak、Anthony S Prokopowicz、Daniel R Goldberg、Tina M Morwick、Amy Gao、Scott Jakes、Mohammed Kashem、Ronald L Magolda、Richard M Soll、Mark R Player、Mark A Bobko、James Rinker、Renee L DesJarlais、Michael P Winters

  DOI：10.1016/s0960-894x(03)00163-x

  日期：2003.4

  The discovery of novel 5,7-disubstituted[1,6]naphthyridines as potent inhibitors of Spleen Tyrosine Kinase (SYK) is discussed. The SAR reveals the necessity for a 7-aryl group with preference towards para substitution and that this in combination with 5-aminoalkylamino substituents further improved the potency of the compounds. The initial SAR as well as a survey of the other positions is discussed

  讨论了新型的5,7-二取代的[1,6]萘啶作为脾酪氨酸激酶（SYK）的有效抑制剂的发现。SAR揭示了7-芳基优先于对位取代的必要性，并且其与5-氨基烷基氨基取代基的结合进一步提高了化合物的效力。详细讨论了初始比吸收率以及其他位置的调查。

表征谱图