Ser-Met-O-Me | 10233-78-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ser-Met-O-Me
• 英文别名: L-Seryl-L-methionin-methylester；l-Seryl-l-methionine methyl ester；methyl (2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-4-methylsulfanylbutanoate
• CAS: 10233-78-0
• 化学式: C₉H₁₈N₂O₄S
• 分子量: 250.319
• InChiKey: ZKXMXGPHBWZQCJ-BQBZGAKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Ser-Met-O-Me 、 N--L-tyrosin 生成 methyl (2S)-2-[[(2S)-3-hydroxy-2-[[(2S)-3-(4-hydroxyphenyl)-2-[(2-nitrophenyl)sulfanylamino]propanoyl]amino]propanoyl]amino]-4-methylsulfanylbutanoate
  参考文献：
  名称：

  YUXNEVICH, A. D.;SYSKOV, I. V.;ROMANOVSKIJ, P. YA.;CHIPENS, G. I.

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl (2S)-2-[[(2S)-3-hydroxy-2-[(2-nitrophenyl)sulfanylamino]propanoyl]amino]-4-methylsulfanylbutanoate 生成 Ser-Met-O-Me
  参考文献：
  名称：

  YUXNEVICH, A. D.;SYSKOV, I. V.;ROMANOVSKIJ, P. YA.;CHIPENS, G. I.

  摘要：

  DOI：

文献信息

• DEPROTECTION METHOD
  申请人：AJINOMOTO CO., INC.

  公开号：US20160024143A1

  公开（公告）日：2016-01-28

  The present invention provides a method of efficiently deprotecting a protected organic compound by catalytic hydrogenation. Specifically, the present invention provides a method of deprotecting an organic compound having at least one functional group selected from the group consisting of a carboxy group, an amino group and a hydroxy group, which is protected by a protecting group represented by the formula (I): R 1 —C(R 2 )(R 3 )-L 1 -   (I) [wherein R 1 is an aryl group optionally having substituent(s), R 2 and R 3 are each independently, a hydrogen atom or an aryl group optionally having substituent(s), and L 1 is a single bond, —O—CO— or —O—CH 2 —], comprising hydrogenation in the presence of a metal catalyst and halogenated acetic acid.

  本发明提供了一种通过催化氢化高效去保护有机化合物的方法。具体而言，本发明提供了一种去保护具有至少一种来自羧基、氨基和羟基的官能团的有机化合物的方法，该官能团由式(I)所表示的保护基所保护，该式中R1为一个芳基，可选地具有取代基，R2和R3分别独立地为氢原子或可选地具有取代基的芳基，L1为单键，-O-CO-或-O-CH2-，包括在金属催化剂和卤代乙酸存在下进行氢化的步骤。
• Deprotection method
  申请人：AJINOMOTO CO., INC.

  公开号：US10442834B2

  公开（公告）日：2019-10-15

  The present invention provides a method of efficiently deprotecting a protected organic compound by catalytic hydrogenation. Specifically, the present invention provides a method of deprotecting an organic compound having at least one functional group selected from the group consisting of a carboxy group, an amino group and a hydroxy group, which is protected by a protecting group represented by the formula (I): R1—C(R2)(R3)-L1-  (I) [wherein R1 is an aryl group optionally having substituent(s), R2 and R3 are each independently, a hydrogen atom or an aryl group optionally having substituent(s), and L1 is a single bond, —O—CO— or —O—CH2—], comprising hydrogenation in the presence of a metal catalyst and halogenated acetic acid.

  本发明提供了一种通过催化氢化对受保护有机化合物进行高效脱保护的方法。具体地说，本发明提供了一种对具有至少一个官能团的有机化合物进行脱保护的方法，该官能团选自由羧基、氨基和羟基组成的组，并受由式（I）表示的保护基团的保护： R1-C(R2)(R3)-L1- (I) [其中 R1 是可选具有取代基的芳基，R2 和 R3 分别独立地为氢原子或可选具有取代基的芳基，L1 是单键、-O-CO- 或 -O-CH2-]，包括在金属催化剂和卤代乙酸存在下进行氢化反应。