Boc-Lys-HEMA | 1259030-78-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Lys-HEMA
• CAS: 1259030-78-8
• 化学式: C₁₇H₃₀N₂O₆
• 分子量: 358.435
• InChiKey: IZFNRDVYWSSBBN-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.67
• 重原子数：
  25.0
• 可旋转键数：
  10.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  116.95
• 氢给体数：
  2.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  甲基丙烯酸羟乙酯 、 N-alpha-叔丁氧羰基-L-赖氨酸 在 N,N'-二环己基碳二亚胺 、 4-二甲氨基吡啶 作用下， 以 乙酸乙酯 为溶剂， 反应 25.0h， 生成 Boc-Lys-HEMA
  参考文献：
  名称：

  Facile Synthesis of Multiamino Vinyl Poly(amino acid)s for Promising Bioapplications

  摘要：

  We presented a general and facile strategy to prepare biocompatible multiamino polymers. Series of new monomers were synthesized by esterification of 2-hydroxyethyl methacrylate (HEMA) and Boc-amino acids, such as Boc-L-phenylalanine, Boc-glycine, Boc-L-alanine, Boc-L-valine, and Boc-L-lysine. Subsequent vinyl polymerization of monomers gave rise to vinyl poly(amino acid)s with a side primary amino group at each unit if deprotected. Both atom transfer radical polymerization (ATRP) and conventional free radical polymerization (FRP) were employed to prepare the multiamino polymers. A well controlled effect upon molecular weight with the standard first-order kinetics was achieved in cases of ATRP, and high molecular weight polymers were obtained via FRP. MTT assay showed that cell survival rates for the multiamino polymers were almost maintained above 90% and that their cytotoxicities were much lower than that of linear PEI (PEI 25000). Zeta potential measurements demonstrated that the vinyl poly(amino acid)s are electropositive, and AFM measurements showed that the vinyl poly(amino acid)s could tightly condense DNA into granular structures at a suitable concentration. The combination of facile availability, controlled productivity, low cytotoxicity and strong binding ability with DNA promises the great potential of the novel multiamino polymers in bioapplications.

  DOI：

  10.1021/bm101060m