(R)-3-[8-(pentafluorophenyl-methoxy)-octanoylamino]-4-trimethylammonio-butyrate | 1192177-71-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-3-[8-(pentafluorophenyl-methoxy)-octanoylamino]-4-trimethylammonio-butyrate
• 英文别名: (3R)-3-[8-[(2,3,4,5,6-pentafluorophenyl)methoxy]octanoylamino]-4-(trimethylazaniumyl)butanoate
• CAS: 1192177-71-1
• 化学式: C₂₂H₃₁F₅N₂O₄
• 分子量: 482.491
• InChiKey: DNPKHHSUGKZLAG-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  33
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  78.5
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• 4-TRIMETHYLAMMONIO-BUTYRATES AS CPT2 INHIBITORS
  申请人：Andjelkovic Mirjana

  公开号：US20090270500A1

  公开（公告）日：2009-10-29

  This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A 1 , R 1 , m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.

  该发明涉及一种新型的4-三甲基氨基丁酸盐，其化学式如下，其中A1、R1、m和n的定义见描述和权利要求书，以及其药用盐。这些化合物抑制肉碱棕榈酰基转移酶（CPT）活性，特别是CPT2活性，并可用作药物。
• US8349893B2
  申请人：——

  公开号：US8349893B2

  公开（公告）日：2013-01-08
• US8673946B2
  申请人：——

  公开号：US8673946B2

  公开（公告）日：2014-03-18
• [EN] 4-TRIMETHYLAMMONIO-BUTYRATES AS CPT2 INHIBITORS<br/>[FR] 4-TRIMÉTHYLAMMONIO-BUTYRATES UTILISÉS COMME INHIBITEURS DE CPT2
  申请人：HOFFMANN LA ROCHE

  公开号：WO2009132979A1

  公开（公告）日：2009-11-05

  This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.