3-diphenylphosphanyl-4-hydroxybenzaldehyde | 896740-39-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-diphenylphosphanyl-4-hydroxybenzaldehyde
• CAS: 896740-39-9
• 化学式: C₁₉H₁₅O₂P
• 分子量: 306.301
• InChiKey: CTBIAPLVHPJRAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.96
• 重原子数：
  22.0
• 可旋转键数：
  4.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  3-diphenylphosphanyl-4-hydroxybenzaldehyde 在 吡啶 、 sodium tetrahydroborate 作用下， 以 二氯甲烷 、 氯仿 、 异丙醇 为溶剂， 反应 48.5h， 生成 propylcarbamic acid 2-diphenylphosphanyl-4-hydroxymethylphenyl ester
  参考文献：
  名称：

  A new drug-release method using the Staudinger ligation

  摘要：

  Many drugs induce severe side-effects caused by their lack of selectivity. One way to overcome this problem is to design a specific system which releases a free drug in a controlled manner. Herein we describe a new way to liberate a drug from a prodrug using the Staudinger ligation as the trigger. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.073
• 作为产物：
  描述：

  4-羟基-3-碘苯甲醛 、 二苯基膦 在 palladium diacetate 、 potassium acetate 作用下， 以 乙腈 为溶剂， 以44%的产率得到3-diphenylphosphanyl-4-hydroxybenzaldehyde
  参考文献：
  名称：

  A new drug-release method using the Staudinger ligation

  摘要：

  Many drugs induce severe side-effects caused by their lack of selectivity. One way to overcome this problem is to design a specific system which releases a free drug in a controlled manner. Herein we describe a new way to liberate a drug from a prodrug using the Staudinger ligation as the trigger. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.03.073