7-(4-diethylamino-6-propylpyrimidin-2-ylamino)-4-trifluoromethyl-2H-chromen-2-one | 1394851-83-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-(4-diethylamino-6-propylpyrimidin-2-ylamino)-4-trifluoromethyl-2H-chromen-2-one
• 英文别名: 7-[[4-(Diethylamino)-6-propylpyrimidin-2-yl]amino]-4-(trifluoromethyl)chromen-2-one
• CAS: 1394851-83-2
• 化学式: C₂₁H₂₃F₃N₄O₂
• 分子量: 420.434
• InChiKey: LCLRUZJGVMZAAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] DÉRIVÉS DE DIAMINOPYRIMIDINE ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：YUHAN CORP

  公开号：WO2012115479A2

  公开（公告）日：2012-08-30

  The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.