| 1107639-73-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1107639-73-5
• 化学式: C₂₄H₄₆O₆Si₂
• 分子量: 486.797
• InChiKey: GDMVSENXIZFNJM-WMNQNKDGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.01
• 重原子数：
  32.0
• 可旋转键数：
  11.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为产物：
  描述：

  乙氧甲酰基亚甲基三苯基膦 、 (4R,5S)-4,5-bis-(tert-butyldimethylsilanyloxy)-6-oxohex-2-(E)-enoic acid ethyl ester 以 甲醇 为溶剂， 以73%的产率得到(2E,6E)-(4R,5R)-4,5-Bis-(tert-butyl-dimethyl-silanyloxy)-octa-2,6-dienedioic acid diethyl ester
  参考文献：
  名称：

  Synthesis of γ-lactones by desymmetrization. A synthesis of (−)-muricatacin

  摘要：

  A short synthesis of the natural potent cytotoxic agent (-)-muricatacin 1 and related unsaturated lactones from a versatile common intermediate, dienedioate 2, derived from D-mannitol or tartaric acid, is described. The strategy depends upon the desymmetrization of 7 by dihydroxylation and elaboration of the hydroxy alkyl sidechain. A route to unsaturated lactones is also described using a cis selective Wittig reaction. Since the enantiomers of 2 are available from the corresponding tartaric acids, this method provides access to both enantiomers of the described compounds and a wide range of derivatives. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.10.020