(R)-P,P-diphenyl-N-(1-(thiophen-2-yl)-3-(thiophen-3-yl)prop-2-yn-1-yl)phosphinic amide | 1251771-84-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (R)-P,P-diphenyl-N-(1-(thiophen-2-yl)-3-(thiophen-3-yl)prop-2-yn-1-yl)phosphinic amide
• CAS: 1251771-84-2
• 化学式: C₂₃H₁₈NOPS₂
• 分子量: 419.508
• InChiKey: RDDHPNPLXHPSFE-JOCHJYFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.42
• 重原子数：
  28.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  29.1
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  3-乙炔基噻吩 、 P,P-diphenyl-N-(thiophen-2-ylmethylene)phosphinic amide 在 (1-(thiophen-2-ylmethyl)pyrrolidin-2-yl)methanol 、 diethylzinc 作用下， 以 二氯甲烷 为溶剂， 反应 57.0h， 以79%的产率得到(R)-P,P-diphenyl-N-(1-(thiophen-2-yl)-3-(thiophen-3-yl)prop-2-yn-1-yl)phosphinic amide
  参考文献：
  名称：

  Design and synthesis of a tridentate ligand inspired by the phenomenon of self-assembly catalysis and its application in the asymmetric alkynylation of N-(diphenylphosphinoyl) imines

  摘要：

  On the basis of the phenomenon of self-assembly catalysis, a tridentate ligand was designed and synthesized in two steps. The application in alkynylation of N-(diphenylphosphinoyl) imines gave the expected products. Aromatic, heteroaromatic N-(diphenylphosphinoyl) imines were employed and gave optically active propargylic amines in good yields (up to 89%) and excellent enantioselectivities (up to 96%) by a simple experimental procedure. The direct use of sulfone amides in the alkynylation of N-(diphenylphosphinoyl) aliphatic imines made this method very attractive. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.07.020