(1R,9R)-5-[6-[2-[6-[(1R,9R)-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl]pyridin-2-yl]-1,3-dioxolan-2-yl]pyridin-2-yl]-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene | 1532527-92-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (1R,9R)-5-[6-[2-[6-[(1R,9R)-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl]pyridin-2-yl]-1,3-dioxolan-2-yl]pyridin-2-yl]-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene
• CAS: 1532527-92-6
• 化学式: C₃₇H₃₈N₄O₂
• 分子量: 570.734
• InChiKey: BGVULGRAIWNJHF-PWGHIRGTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  43
• 可旋转键数：
  4
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  70
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (1R,9R)-5-[6-[2-[6-[(1R,9R)-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl]pyridin-2-yl]-1,3-dioxolan-2-yl]pyridin-2-yl]-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene 在 盐酸 作用下， 以 水 为溶剂， 以100%的产率得到bis[6-[(1R,9R)-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl]pyridin-2-yl]methanone
  参考文献：
  名称：

  A Family of Immobilizable Chiral Bis(pinenebipyridine) Ligands

  摘要：

  New enantiopure ligands containing two (-)-5,6-pinenebipyridine units connected by a bridge situated in position 6 of the bipyridines have been prepared. The chemically addressable groups of the bridging (hydroxyl or keto) can be covalently bound to various supports in order to heterogenize the ligand.

  DOI：

  10.1055/s-0033-1339847
• 作为产物：
  描述：

  bis(6-(2-methyl-1,3-dioxolan-2-yl)pyridin-2-yl)methanone 在 盐酸 、 硫酸 、 碘 作用下， 以 水 、 丙酮 、 苯 为溶剂， 反应 209.5h， 生成 (1R,9R)-5-[6-[2-[6-[(1R,9R)-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-trien-5-yl]pyridin-2-yl]-1,3-dioxolan-2-yl]pyridin-2-yl]-10,10-dimethyl-6-azatricyclo[7.1.1.02,7]undeca-2(7),3,5-triene
  参考文献：
  名称：

  A Family of Immobilizable Chiral Bis(pinenebipyridine) Ligands

  摘要：

  New enantiopure ligands containing two (-)-5,6-pinenebipyridine units connected by a bridge situated in position 6 of the bipyridines have been prepared. The chemically addressable groups of the bridging (hydroxyl or keto) can be covalently bound to various supports in order to heterogenize the ligand.

  DOI：

  10.1055/s-0033-1339847

文献信息

• A Family of Immobilizable Chiral Bis(pinenebipyridine) Ligands
  作者：Olimpia Mamula、Alpár Pöllnitz、Radek Skupienski、Helen Stoeckli-Evans、Aurélien Crochet、Anca Silvestru、Katharina Fromm

  DOI：10.1055/s-0033-1339847

  日期：——

  New enantiopure ligands containing two (-)-5,6-pinenebipyridine units connected by a bridge situated in position 6 of the bipyridines have been prepared. The chemically addressable groups of the bridging (hydroxyl or keto) can be covalently bound to various supports in order to heterogenize the ligand.