(S)-(2-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin) | 1251536-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-(2-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin)
• CAS: 1251536-53-4
• 化学式: C₁₈H₁₉N₅
• 分子量: 305.382
• InChiKey: RNXIKDMGTWAQQD-ZDUSSCGKSA-N

反应信息

• 作为反应物：
  描述：

  (S)-(2-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin) 、 苯甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 ((S)-(2-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin)-1-yl)(phenyl)methanone
  参考文献：
  名称：

  Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists

  摘要：

  The Hedgehog (Hh) signaling pathway regulates cell proliferation and differentiation in developing tissues, and abnormal activation of the Hh pathway has been linked to several tumor subsets. As a transducer of Hh signaling, the GPCR-like protein Smoothened (Smo) is a promising target for disruption of unregulated Hh signaling. A series of 1-amino-4-arylphthalazines was developed as potent and orally bioavailable inhibitors of Smo. A representative compound from this class demonstrated significant tumor volume reduction in a mouse medulloblastoma model. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.110
• 作为产物：
  描述：

  、 吡啶-4-硼酸 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 水 、 甲苯 为溶剂， 生成 (S)-(2-methyl-4-(4-(pyridin-4-yl)phthalazin-1-yl)piperazin)
  参考文献：
  名称：

  Design of 1-piperazinyl-4-arylphthalazines as potent Smoothened antagonists

  摘要：

  The Hedgehog (Hh) signaling pathway regulates cell proliferation and differentiation in developing tissues, and abnormal activation of the Hh pathway has been linked to several tumor subsets. As a transducer of Hh signaling, the GPCR-like protein Smoothened (Smo) is a promising target for disruption of unregulated Hh signaling. A series of 1-amino-4-arylphthalazines was developed as potent and orally bioavailable inhibitors of Smo. A representative compound from this class demonstrated significant tumor volume reduction in a mouse medulloblastoma model. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.110