N'-((phenylsulfonyl)oxy)isonicotinimidamide | 767322-41-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-((phenylsulfonyl)oxy)isonicotinimidamide
• 英文别名: N'-[(phenylsulfonyl)oxy]pyridine-4-carboximidamide；[(Z)-[amino(pyridin-4-yl)methylidene]amino] benzenesulfonate
• CAS: 767322-41-8
• 化学式: C₁₂H₁₁N₃O₃S
• mdl: MFCD01986049
• 分子量: 277.304
• InChiKey: BYMCEYLGDPMQBA-UHFFFAOYSA-N

物化性质

• 沸点：
  425.6±37.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-吡啶基偕胺肟 、 苯磺酰氯 在 三乙胺 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以55%的产率得到N'-((phenylsulfonyl)oxy)isonicotinimidamide
  参考文献：
  名称：

  Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity

  摘要：

  We describe herein the synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes, from the reaction of amidoximes with the corresponding sulfonyl chlorides, in low to excellent yields. Evaluation of their antioxidant activity has shown that 17 out of 28 compounds highly compete DMSO for hydroxyl radicals, while five of them inhibit lipid peroxidation. Combining the reducing and anti-lipid peroxidation ability it seems that compounds 13 and 31 could be used as lead molecules.

  DOI：

  10.1016/j.ejmech.2014.04.040

文献信息

• Synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes and evaluation of their antioxidant and lipid peroxidation activity
  作者：Ismini Doulou、Christos Kontogiorgis、Alexandros E. Koumbis、Eleni Evgenidou、Dimitra Hadjipavlou-Litina、Konstantina C. Fylaktakidou

  DOI：10.1016/j.ejmech.2014.04.040

  日期：2014.6

  We describe herein the synthesis of stable aromatic and heteroaromatic sulfonyl-amidoximes, from the reaction of amidoximes with the corresponding sulfonyl chlorides, in low to excellent yields. Evaluation of their antioxidant activity has shown that 17 out of 28 compounds highly compete DMSO for hydroxyl radicals, while five of them inhibit lipid peroxidation. Combining the reducing and anti-lipid peroxidation ability it seems that compounds 13 and 31 could be used as lead molecules.