4-(3-chlorophenyl)-2-methyl-6-[2-(3-pyridine) ethoxy] methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 5-(3,3-diphenylpropyl) ester | 314775-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-chlorophenyl)-2-methyl-6-[2-(3-pyridine) ethoxy] methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 5-(3,3-diphenylpropyl) ester
• 英文别名: 5-(3,3-diphenylpropane-1-yl) 4-(3-chlorophenyl)-2-methyl-6-(2-(3-piridine)ethoxymethyl)-1,4-dihydropyridine-3,5-dicarboxylate；4-(3-Chlorophenyl)-5-(3,3-diphenylpropoxycarbonyl)-2-methyl-6-(2-pyridin-3-ylethoxymethyl)-1,4-dihydropyridine-3-carboxylic acid
• CAS: 314775-20-7
• 化学式: C₃₇H₃₅ClN₂O₅
• 分子量: 623.148
• InChiKey: HBCWHSXTHWLMGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  45
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  97.8
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-(3-chlorophenyl)-2-methyl-6-[2-(3-pyridine) ethoxy] methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 5-(3,3-diphenylpropyl) ester 在 cerium(IV)diammonium nitrate 作用下， 以 水 、 丙酮 为溶剂， 反应 0.5h， 以85%的产率得到4-(3-chlorophenyl)-5-[(3,3-diphenylpropoxy) carbonyl]-2-methyl-6-[[2-(pyridine-3-yl) ethoxy] methyl] nicotinic acid
  参考文献：
  名称：

  Pyrimidine derivatives and new pyridine derivatives

  摘要：

  Achirai嘧啶衍生物和以下结构式或其类似物的吡啶衍生物具有选择性N型钙通道拮抗活性，并在口服时显示镇痛作用。它们可用作与N型钙通道相关的疼痛和各种疾病的治疗药物。

  公开号：

  US20040009991A1
• 作为产物：
  描述：

  3-(2-cyanoethyl) 5-(3,3-diphenylpropane-1-yl) 4-(3-chlorophenyl)-2-methyl-6-(2-(3-pyridine)ethoxymethyl)-1,4-dihydropyrimidine-3,5-dicarboxylate 在 盐酸 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以42%的产率得到4-(3-chlorophenyl)-2-methyl-6-[2-(3-pyridine) ethoxy] methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 5-(3,3-diphenylpropyl) ester
  参考文献：
  名称：

  EP1191021

  摘要：

  公开号：

文献信息

• NOVEL PYRIMIDINE DERIVATIVE AND NOVEL PYRIDINE DERIVATIVE
  申请人：Ajinomoto Co., Inc.

  公开号：EP1318147A1

  公开（公告）日：2003-06-11

  Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels.

  非手性嘧啶衍生物和以下结构式或其类似物的吡啶衍生物具有选择性N型钙通道拮抗活性，并且当口服时表现出镇痛作用。它们可用作与N型钙通道相关的疼痛和各种疾病的治疗药物。
• Dihydropyridine derivatives
  申请人：AJINOMOTO CO. INC

  公开号：US20020147222A1

  公开（公告）日：2002-10-10

  Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: 1 analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.

  提供具有选择性N型钙通道拮抗活性的化合物。以下式表示的二氢吡啶衍生物：1的类似物及其药用盐具有选择性抑制N型钙通道作用的活性，它们可用作与N型钙通道相关的各种疾病的治疗剂。
• DIHYDROPYRIDINE DERIVATIVE
  申请人：Ajinomoto Co., Inc.

  公开号：EP1191021A1

  公开（公告）日：2002-03-27

  Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula: analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.

  提供了具有选择性 N 型钙通道拮抗活性的化合物。下式所代表的二氢吡啶衍生物： 其类似物及其药学上可接受的盐类具有选择性抑制 N 型钙通道作用的活性，可用作与 N 型钙通道有关的各种疾病的治疗剂。
• US7247645B2
  申请人：——

  公开号：US7247645B2

  公开（公告）日：2007-07-24
• Pyrimidine derivatives and new pyridine derivatives
  申请人：AJINOMOTO CO., INC.

  公开号：US20040009991A1

  公开（公告）日：2004-01-15

  Achirai pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when they were taken orally. They are useful as therapeutic agents for pains and various diseases associated with the N-type calcium channels. 1

  Achirai嘧啶衍生物和以下结构式或其类似物的吡啶衍生物具有选择性N型钙通道拮抗活性，并在口服时显示镇痛作用。它们可用作与N型钙通道相关的疼痛和各种疾病的治疗药物。