Zamzetoclax | 2388470-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Zamzetoclax
• 英文别名: N-[(3'R,4S,6'R,7'S,8'E,11'S)-7-chloro-7'-methoxy-11'-methyl-13',15'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13λ6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,13,16(25),17,19(24)-pentaene]-13'-yl]-3-methoxy-1-methylpyrazole-4-carboxamide
• CAS: 2388470-64-0
• 化学式: C₃₈H₄₆ClN₅O₆S
• 分子量: 736.3
• InChiKey: GRGIAFGOQJYTKU-YSCNSAAASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  51
• 可旋转键数：
  4
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  133
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• MCL-1 inhibitors
  申请人：Gilead Sciences, Inc.

  公开号：US10988451B2

  公开（公告）日：2021-04-27

  The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

  本公开内容一般涉及可用于治疗癌症方法的化合物和药物组合物。
• Processes and intermediates for preparing MCL1 inhibitors
  申请人：Gilead Sciences, Inc.

  公开号：US11325891B2

  公开（公告）日：2022-05-10

  The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.

  本公开提供了制备 MCL1 抑制剂或其盐及相关关键中间体的方法。
• MCL-1 INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20200331870A1

  公开（公告）日：2020-10-22

  The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
• PROCESSES AND INTERMEDIATES FOR PREPARING MCL1 INHIBITORS
  申请人：Gilead Sciences, Inc.

  公开号：US20210179570A1

  公开（公告）日：2021-06-17

  The present disclosure provides methods for preparing MCL1 inhibitors or a salt thereof and related key intermediates.