2-((4-(hydrazinocarbonyl)phenyl)carbamoyl)benzoic acid | 1318203-82-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((4-(hydrazinocarbonyl)phenyl)carbamoyl)benzoic acid
• 英文别名: 2-((4-(Hydrazinecarbonyl)phenyl)carbamoyl)benzoic acid；2-[[4-(hydrazinecarbonyl)phenyl]carbamoyl]benzoic acid
• CAS: 1318203-82-5
• 化学式: C₁₅H₁₃N₃O₄
• 分子量: 299.286
• InChiKey: XVSFOJWHSBTUKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-((4-(hydrazinocarbonyl)phenyl)carbamoyl)benzoic acid 、 N-(Acetylphenyl)-2-carboxybenzamide 在 溶剂黄146 作用下， 反应 5.0h， 以45%的产率得到2-((4-(1-(2-(4-(2-carboxybenzamido)benzoyl)hydrazono)ethyl)phenyl)carbamoyl)benzoic acid
  参考文献：
  名称：

  Synthesis of new phenylcarbamoylbenzoic acid derivatives and evaluation of their in vitro antioxidant activity

  摘要：

  In this study, new derivatives of phenylcarbamoylbenzoic acid were synthesized and evaluated for their in vitro antioxidant activity. The target compounds were prepared by bonding pharmacophoric moieties possessing antioxidant activity, including hydrazones, acid hydrazides, imino, Schiff's bases, and phthalimides with phenylcarbamoylbenzoic acid via simple and efficient synthetic strategies. The structures of the newly synthesized compounds were confirmed by physical and spectral data. The in vitro antioxidant activity was carried out using ABTS antioxidant assay. All the tested compounds showed low antioxidant activity except compound 7, which showed moderate antioxidant activity compared with ascorbic acid.

  DOI：

  10.1007/s00044-011-9677-2
• 作为产物：
  描述：

  苯酐 在 一水合肼 作用下， 以 乙醇 、 乙酸乙酯 为溶剂， 反应 8.0h， 生成 2-((4-(hydrazinocarbonyl)phenyl)carbamoyl)benzoic acid
  参考文献：
  名称：

  Synthesis of new phenylcarbamoylbenzoic acid derivatives and evaluation of their in vitro antioxidant activity

  摘要：

  In this study, new derivatives of phenylcarbamoylbenzoic acid were synthesized and evaluated for their in vitro antioxidant activity. The target compounds were prepared by bonding pharmacophoric moieties possessing antioxidant activity, including hydrazones, acid hydrazides, imino, Schiff's bases, and phthalimides with phenylcarbamoylbenzoic acid via simple and efficient synthetic strategies. The structures of the newly synthesized compounds were confirmed by physical and spectral data. The in vitro antioxidant activity was carried out using ABTS antioxidant assay. All the tested compounds showed low antioxidant activity except compound 7, which showed moderate antioxidant activity compared with ascorbic acid.

  DOI：

  10.1007/s00044-011-9677-2

文献信息

• Synthesis of new phenylcarbamoylbenzoic acid derivatives and evaluation of their in vitro antioxidant activity
  作者：Waleed A. Bayoumi、Magda A. Elsayed

  DOI：10.1007/s00044-011-9677-2

  日期：2012.8

  In this study, new derivatives of phenylcarbamoylbenzoic acid were synthesized and evaluated for their in vitro antioxidant activity. The target compounds were prepared by bonding pharmacophoric moieties possessing antioxidant activity, including hydrazones, acid hydrazides, imino, Schiff's bases, and phthalimides with phenylcarbamoylbenzoic acid via simple and efficient synthetic strategies. The structures of the newly synthesized compounds were confirmed by physical and spectral data. The in vitro antioxidant activity was carried out using ABTS antioxidant assay. All the tested compounds showed low antioxidant activity except compound 7, which showed moderate antioxidant activity compared with ascorbic acid.