N6-Glutaryllysine | 52685-14-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N6-Glutaryllysine
• 英文别名: (2S)-2-amino-6-(4-carboxybutanoylamino)hexanoic acid
• CAS: 52685-14-0
• 化学式: C₁₁H₂₀N₂O₅
• 分子量: 260.29
• InChiKey: BDTLWEOZKBIUOL-QMMMGPOBSA-N

物化性质

• 沸点：
  590.8±50.0 °C(Predicted)
• 密度：
  1.243±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.2
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Influenza virus neutralizing peptidomimetic compounds
  申请人：Janssen Vaccines & Prevention B.V.

  公开号：US10738083B2

  公开（公告）日：2020-08-11

  The present invention relates to novel peptidomimetic compounds that are capable of binding to and/or neutralizing influenza viruses, in particular influenza A viruses of phylogenetic group 1, and to pharmaceutical compositions comprising such compounds. The invention also relates to the use of the peptidomimetic compounds in the diagnosis, prophylaxis and/or treatment of influenza virus infections.

  本发明涉及能够结合和/或中和流感病毒（尤其是系统发育群1的甲型流感病毒）的新型拟肽化合物，以及包含此类化合物的药物组合物。本发明还涉及拟肽化合物在诊断、预防和/或治疗流感病毒感染中的用途。
• INFLUENZA VIRUS NEUTRALIZING PEPTIDOMIMETIC COMPOUNDS
  申请人：Janssen Vaccines & Prevention B.V.

  公开号：EP3294753A1

  公开（公告）日：2018-03-21
• [EN] INFLUENZA VIRUS NEUTRALIZING PEPTIDOMIMETIC COMPOUNDS<br/>[FR] COMPOSÉS PEPTIDOMIMÉTIQUES NEUTRALISANT LE VIRUS INFLUENZA
  申请人：JANSSEN VACCINES & PREVENTION BV

  公开号：WO2016180826A1

  公开（公告）日：2016-11-17

  The present invention relates to novel peptidomimetic compounds that are capable of binding to and/or neutralizing influenza viruses, in particular influenza A viruses of phylogenetic group 1, and to pharmaceutical compositions comprising such compounds. The invention also relates to the use of the peptidomimetic compounds in the diagnosis, prophylaxis and/or treatment of influenza virus infections.