cis-2-Phenylcyclohexyl-mesylat | 40960-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cis-2-Phenylcyclohexyl-mesylat
• 英文别名: [(1R,2R)-2-phenylcyclohexyl] methanesulfonate
• CAS: 40960-71-2；40960-75-6
• 化学式: C₁₃H₁₈O₃S
• 分子量: 254.35
• InChiKey: QDTSLCFOVSACBX-CHWSQXEVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cis-2-Phenylcyclohexyl-mesylat 在 硼烷四氢呋喃络合物 、 potassium thioacetate 、 2-碘酰基苯甲酸 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 生成 2-苯基环己酮
  参考文献：
  名称：

  Influence of chiral thiols on the diastereoselective synthesis of γ-lactams from cyclic anhydrides

  摘要：

  The synthesis of gamma-lactams from both four-component and imine-anhydride reactions is reported. The synthesis of 2-phenylcyclohexanethiol is described and this compound was evaluated along with an additional seven chiral thiols. A range of selectivity and yields was observed and comparisons to established reactions are made in order to account for the observed reactivity. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.027
• 作为产物：
  描述：

  2-苯基环己烷-1-醇 、 甲基磺酰氯 在 吡啶 作用下， 以48%的产率得到cis-2-Phenylcyclohexyl-mesylat
  参考文献：
  名称：

  Influence of chiral thiols on the diastereoselective synthesis of γ-lactams from cyclic anhydrides

  摘要：

  The synthesis of gamma-lactams from both four-component and imine-anhydride reactions is reported. The synthesis of 2-phenylcyclohexanethiol is described and this compound was evaluated along with an additional seven chiral thiols. A range of selectivity and yields was observed and comparisons to established reactions are made in order to account for the observed reactivity. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.027

文献信息

• Conformational study of phenethylamine receptor sites. 1. Syntheses of semirigid analogs of .beta.-methylamphetamine
  作者：Edward E. Smissman、Thomas L. Pazdernik

  DOI：10.1021/jm00259a005

  日期：1973.1