3-(difluoromethoxy)-2-methylcyclopent-2-enone | 1231894-89-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 乙烯酯类
• 英文名称: 3-(difluoromethoxy)-2-methylcyclopent-2-enone
• 英文别名: 3-(Difluoromethoxy)-2-methylcyclopent-2-en-1-one；3-(difluoromethoxy)-2-methylcyclopent-2-en-1-one
• CAS: 1231894-89-5
• 化学式: C₇H₈F₂O₂
• 分子量: 162.136
• InChiKey: ABTGVFZPKLWDKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-甲基-1,3-环戊二酮 、 二氟氯乙酸乙酯 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 以126 mg的产率得到3-(difluoromethoxy)-2-methylcyclopent-2-enone
  参考文献：
  名称：

  通过ClCF2CO2Et对1,3-二酮进行O-二氟甲基化合成二氟甲基烯醇醚的新方法。

  摘要：

  已经开发了一种简便，有效的单步骤方案，该方案通过从ClCF2CO2Et原位生成二氟卡宾，通过1,3-二酮的O-二氟甲基化合成二氟甲基烯醇醚衍生物。官能团耐受性，反应的可扩展性和温和的反应条件使其成为合成制药和农用化学工业感兴趣的生物学相关二氟甲基醚的有吸引力的方案。

  DOI：

  10.1039/c5ob00020c

文献信息

• O-Difluoromethylation of 1,3-diones with S-difluoromethyl sulfonium salt
  作者：Chun-Bo Yue、Jin-Hong Lin、Ji Cai、Cheng-Pan Zhang、Gang Zhao、Ji-Chang Xiao、HengFeng Li

  DOI：10.1039/c6ra06338a

  日期：——

  The O-difluoromethylation of 1,3-diones with S-difluoromethyl sulfonium salt is described. The sulfonium salt was previously believed to be a direct difluoromethylation reagent, but our mechanistic investigation reveals that the O-difluoromethylation reaction proceeds not only via the direct transfer of the CF2H group, but also via a difluorocarbene process. This work represents the first protocol

  所述Ô的1,3-二酮与-difluoromethylation小号二氟甲基锍盐进行说明。previously盐以前被认为是直接的二氟甲基化试剂，但是我们的机理研究表明，O-二氟甲基化反应不仅通过CF 2 H基团的直接转移进行，而且还通过二氟卡宾方法进行。这项工作代表了无环1,3-二酮的轻度O-二氟甲基化的第一个方案。
• Base-free O-difluoromethylation of 1,3-diones with difluorocarbene
  作者：Can Liu、Xiao-Yun Deng、Xian-Liang Zeng、Gang Zhao、Jin-Hong Lin、Hongqing Wang、Ji-Chang Xiao

  DOI：10.1016/j.jfluchem.2016.10.011

  日期：2016.12

  The base-free O-difluoromethylation of 1,3-diones with difluorocarbene generated from difluoromethylene phosphobetaine (Ph3P+CF2CO2−) is described. The convenient reactions proceeded smoothly to give difluoromethyl enol ethers in moderate to good yields.

  游离碱- O-的二氟亚甲基从生成磷酸酯1,3-二酮与二氟卡宾二氟甲基（PH 3 P + CF 2 CO 2 - ）进行说明。方便的反应顺利进行，以中等至良好的产率得到二氟甲基烯醇醚。
• New Electrophilic Bromodifluoromethylation and Pentafluoroethylation Reagents
  作者：Ji-Chang Xiao、Cheng-Pan Zhang、Hai-Ping Cao、Zong-Ling Wang、Chun-Tao Zhang、Qing-Yun Chen

  DOI：10.1055/s-0029-1219579

  日期：2010.4

  S-(fluoroalkyl)diphenylsulfonium salts have been successfully synthesized from the reaction between fluoroalkylsul­finates and triflic anhydride in dichloromethane through a one-pot procedure. These S-(fluoroalkyl)diphenylsulfonium salts have been demonstrated to be effective reagents to fluoroalkylate C-nucleophilic substrates. Ionic substitution and radical or halogenophilic mechanism might be all involved in the reactions.

  在二氯甲烷中，氟烷基硫酸盐与三氟酸酐发生反应，通过一锅程序成功合成了 S-（氟烷基）二苯基锍盐。这些 S-（氟烷基）二苯基锍盐已被证明是氟烷基化 C-亲核底物的有效试剂。这些反应可能涉及离子取代、自由基或亲卤机制。
• Selective <i>O</i>-Difluoromethylation of 1,3-Diones by Bromodifluoromethylating Reagents
  作者：Guokai Liu、Xin Wang、Xiu-Hua Xu、Xu Lu、Etsuko Tokunaga、Seiji Tsuzuki、Norio Shibata

  DOI：10.1021/ol4000313

  日期：2013.3.1

  The regioselective Odifluoromethylation of 1,3-diones was achieved via in situ generation of difluorocarbene from bromodifluoromethylating reagents in the presence of an organic base. A wide variety of difluormethyl enol ethers were obtained in good to excellent yields. The reaction mechanism is discussed based on ab initio calculations (kcal/mol).
• Selective O-difluoromethylation of 1,3-diones using S-(difluoromethyl) sulfonium salt
  作者：Guo-Kai Liu、Xin Li、Wen-Bing Qin、Wei-Feng Lin、Li-Ting Lin、Jia-Yi Chen、Jian-Jian Liu

  DOI：10.1016/j.cclet.2019.03.036

  日期：2019.8

  A facile and highly efficient approach for selective O-difluoromethylation of 1,3-diones by recently developed bench-stable S-(difluoromethyl)sulfonium salt was described. And a broad range of difluoromthyl enol ethers were readily accessed in good to excellent yields under mild reaction conditions. Mechanistic studies revealed that the O-difluoromethylation reaction proceeds mainly via a difluorocarbene pathway. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.