AABE | 332346-57-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: AABE
• 英文别名: 2-[[(2S)-2-[bis(carboxymethyl)amino]-3-[4-(prop-2-enoylamino)phenyl]propyl]-(carboxymethyl)amino]acetic acid
• CAS: 332346-57-3
• 化学式: C₂₀H₂₅N₃O₉
• 分子量: 451.433
• InChiKey: FRVBGHYWGXFOEW-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.1
• 重原子数：
  32
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  185
• 氢给体数：
  5
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 反应 14.0h， 生成 AABE
  参考文献：
  名称：

  Engineering antibodies that bind irreversibly

  摘要：

  本发明提供了一种突变抗体，包括一个反应位点，该反应位点在野生型抗体中不存在，以及一个特异性结合于金属螯合物的互补决定区，其中该反应位点位于互补决定区的附近或内部。

  公开号：

  US20060210571A1

文献信息

• Engineered antibody fragment that irreversibly binds an antigen
  申请人：Meares F. Claude

  公开号：US20060063209A1

  公开（公告）日：2006-03-23

  The present invention provides mutant antibodies with infinite affinity for a target antigen. The antibodies comprise a mutant amino acid at a position within or proximate to a complimentarity determining region of the antibody and a linker covalently bound to the mutant amino acid, the linker comprising a reactive functional group. Subsequent to binding an antigen, the reactive functional group is converted to a covalent bond by reaction with a group of complementary reactivity on the bound antigen. The invention also provides bispecific antibodies with infinite binding affinity that comprise a second domain that specifically binds a metal chelate. The invention further provides methods of using such antibodies to diagnose and treat diseases and conditions.

  本发明提供了对目标抗原具有无限亲和力的突变抗体。这种抗体包括位于抗体互补决定区内或附近位置的突变氨基酸，以及与突变氨基酸共价结合的连接体，连接体包括反应性官能团。在结合抗原后，活性官能团通过与结合抗原上的互补反应基团反应转化为共价键。本发明还提供了具有无限结合亲和力的双特异性抗体，该抗体包含第二个结构域，可特异性结合金属螯合物。本发明进一步提供了使用这种抗体诊断和治疗疾病和病症的方法。
• ENGINEERED ANTIBODY FRAGMENT THAT IRREVERSIBLY BINDS AN ANTIGEN
  申请人：The Regents of the University of California

  公开号：EP1789087A2

  公开（公告）日：2007-05-30
• [EN] ENGINEERED ANTIBODY FRAGMENT THAT IRREVERSIBLY BINDS AN ANTIGEN<br/>[FR] FRAGMENT D'ANTICORPS GENETIQUEMENT MODIFIE QUI SE LIE A UN ANTIGENE DE MANIERE IRREVERSIBLE
  申请人：UNIV CALIFORNIA

  公开号：WO2006033742A2

  公开（公告）日：2006-03-30

  The present invention provides mutant antibodies with infinite affinity for a target antigen. The antibodies comprise a mutant amino acid at a position within or proximate to a complimentarity determining region of the antibody and a linker covalently bound to the mutant amino acid, the linker comprising a reactive functional group. Subsequent to binding an antigen, the reactive functional group is converted to a covalent bond by reaction with a group of complementary reactivity on the bound antigen. The invention also provides bispecific antibodies with infinite binding affinity that comprise a second domain that specifically binds a metal chelate. The invention further provides methods of using such antibodies to diagnose and treat diseases and conditions.