4-(5-bromopyridin-2-yl)benzonitrile | 916653-46-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(5-bromopyridin-2-yl)benzonitrile
• 英文别名: 4-(5-Bromo-2-pyridinyl)benzonitrile
• CAS: 916653-46-8
• 化学式: C₁₂H₇BrN₂
• 分子量: 259.105
• InChiKey: HRHXBSYSUDDCGY-UHFFFAOYSA-N

物化性质

• 沸点：
  380.4±32.0 °C(Predicted)
• 密度：
  1.55±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  36.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(5-bromopyridin-2-yl)benzonitrile 在 四(三苯基膦)钯 、 六正丁基二锡 作用下， 以77%的产率得到3,3'-bipyridine bisbenzonitrile
  参考文献：
  名称：

  Pentamidine analogs as inhibitors of [3H]MK-801 and [3H]ifenprodil binding to rat brain NMDA receptors

  摘要：

  The anti-protozoal drug pentamidine is active against opportunistic Pneumocystis pneumonia, but in addition has several other biological targets, including the NMDA receptor (NR). Here we describe the inhibitory potencies of 76 pentamidine analogs at 2 binding sites of the NR, the channel binding site labeled with [H-3]MK-801 and the [H-3]ifenprodil binding site. Most analogs acted weaker at the ifenprodil than at the channel site. The spermine-sensitivity of NR inhibition by the majority of the compounds was reminiscent of other long-chain dicationic NR blockers. The potency of the parent compound as NR blocker was increased by modifying the heteroatoms in the bridge connecting the 2 benzamidine moieties and also by integrating the bridge into a seven-membered ring. Docking of the 45 most spermine-sensitive bisbenzamidines to a recently described acidic interface between the N-terminal domains of GluN1 and GluN2B mediating polyamine stimulation of the NR revealed the domain contributed by GluN1 as the most relevant target. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.06.012
• 作为产物：
  描述：

  2,5-二溴吡啶 、 4-(4,4,5,5-四甲基-1,3,2-二恶硼)苯甲腈 在 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 乙醇 、 甲苯 为溶剂， 以31%的产率得到4-(5-bromopyridin-2-yl)benzonitrile
  参考文献：
  名称：

  플루오란텐 유도체 및 이를 포함하는 유기 전계발광 소자

  摘要：

  提供了一个被标记为化学式1的氟兰汀衍生物。[化学式1] [在上述化学式1中，每个取代基的定义如同详细说明中所定义的。]

  公开号：

  KR20150137230A

文献信息

• 3차 아민 유도체 및 이를 포함한 유기 전계 발광 소자
  申请人：Lapto Co., Ltd. 주식회사 랩토(120120213992) Corp. No ▼ 131111-0274298BRN ▼129-86-56546

  公开号：KR102060645B1

  公开（公告）日：2019-12-30

  UV 영역의 고에너지 외부광원을 효과적으로 흡수하여 유기 전계 발광 소자 내부의 유기물들의 손상을 최소화시킴으로써 유기 전계 발광 소자의 실질적인 수명 향상에 기여하는 3차 아민 유도체를 제공한다. 본 발명에 따른 유기 전계 발광 소자는, 제1 전극, 제2 전극; 및 상기 제1 전극과 제2 전극 사이에 배치된 1층 이상의 유기물층을 포함하고, 상기 유기물층은 하기 화학식 1로 표시되는 3차 아민 유도체를 포함한다.[화학식 1] (상기 화학식 1에서, Z1, Z2 및 Z3은 각각 독립적으로 O 또는 S 이다.)

  通过有效吸收UV区域的高能外部光源，提供对有机电致发光器件内部有机物的损伤最小化，从而改善有机电致发光器件的实际寿命的第三类胺衍生物。根据本发明的有机电致发光器件包括第1电极，第2电极；以及位于所述第1电极和第2电极之间的1层以上的有机物层，所述有机物层包括如下化学式1所示的第三类胺衍生物。[化学式1]（在上述化学式1中，Z1，Z2和Z3分别独立地为O或S。）
• 5-Bromo-2-pyridylzinc reagent; direct preparation and its coupling reactions
  作者：Reuben D. Rieke、Seung-Hoi Kim

  DOI：10.1016/j.tetlet.2010.11.041

  日期：2011.1

  A facile synthetic route to the direct preparation of 5-bromo-2-pyridylzinc iodide has been developed. Treatment of 5-bromo-2-iodopyridine with active zinc gave rise to the selective oxidative addition to C–I bond under mild conditions. The resulting organozinc iodide has been used in the variety of coupling reactions affording the corresponding cross-coupling product.

  已经开发了一种直接制备5-溴-2-吡啶基碘化锌的简便合成途径。用活性锌处理5-溴-2-碘吡啶可在温和条件下选择性氧化成C-1键。所得的有机碘化锌已用于各种偶联反应中，从而提供了相应的交叉偶联产物。
• [EN] IMIDAZOLE BIARYL COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS<br/>[FR] COMPOSÉS IMIDAZOLE BIARYLE EN TANT QU'INHIBITEURS DE LA S-NITROSOGLUTATHION RÉDUCTASE
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2016046782A1

  公开（公告）日：2016-03-31

  The present disclosure is directed to compounds of formula (Ie) and pharmaceutically acceptable salts thereof, wherein A, B, R1, R2, m, n, X1, X2, X3 and X4 are as defined herein, which are active as inhibitors of S-Nitrosoglutathione reductase (GSNOR). These compounds prevent, inhibit, or suppress the action of GSNOR and are therefore useful in the treatment of GSNOR mediated diseases, disorders, syndromes or conditions such as, e.g., pulmonary hypertension, acute respiratory distress syndrome (ARDS), asthma, bronchospasm, cough, pneumonia, pulmonary fibrosis, interstitial lung diseases, cystic fibrosis and chronic obstructive pulmonary disease (COPD).

  本公开涉及式(Ie)的化合物及其药用盐，其中A、B、R1、R2、m、n、X1、X2、X3和X4如本文所定义，这些化合物作为S-硝基谷胱甘肽还原酶(GSNOR)的抑制剂具有活性。这些化合物可以防止、抑制或抑制GSNOR的作用，因此在治疗GSNOR介导的疾病、紊乱、综合征或病况方面具有用处，例如肺动脉高压、急性呼吸窘迫综合征(ARDS)、哮喘、支气管痉挛、咳嗽、肺炎、肺纤维化、间质性肺疾病、囊性纤维化和慢性阻塞性肺病(COPD)。
• COMPOUND AND ORGANIC ELECTRONIC DEVICE USING THE SAME
  申请人：NICHEM FINE TECHNOLOGY CO., LTD.

  公开号：US20190092745A1

  公开（公告）日：2019-03-28

  Provided are a novel compound and an organic electronic device using the same. The novel compound is represented by the following Formula (I): wherein Y is an oxygen atom or a sulfur atom; X 1 and X 2 are each independently C(R a ), the two (R a )s are the same or different, and the two (R a )s are joined together to form a first aryl ring; X 3 and X 4 are each independently C(R b ), the two (R b )s are the same or different, and the two (R b )s are joined to form a second aryl ring or a heteroaryl ring.

  提供了一种新化合物和使用该化合物的有机电子器件。该新化合物由以下式子（I）表示：其中Y是氧原子或硫原子；X1和X2各自独立地为C（Ra），两个（Ra）相同或不同，并且两个（Ra）结合在一起形成第一个芳香环；X3和X4各自独立地为C（Rb），两个（Rb）相同或不同，并且两个（Rb）结合在一起形成第二个芳香环或杂环。
• Linear dicationic terphenyls and their aza analogues as antiparasitic agents
  申请人：Tidwell R. Richard

  公开号：US20070232621A1

  公开（公告）日：2007-10-04

  Novel dicationic terphenyl compounds and their aza analogues. Methods for combating microbial infections with novel dicationic terphenyl compounds and their aza analogues. Processes for synthesizing novel dicationic terphenyl compounds and their aza analogues.

  小说二价离子三苯基化合物及其氮杂环类似物。使用小说二价离子三苯基化合物及其氮杂环类似物对微生物感染进行作战的方法。合成小说二价离子三苯基化合物及其氮杂环类似物的过程。