(9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-yl)hydrazine | 717913-83-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: (9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-yl)hydrazine
• CAS: 717913-83-2
• 化学式: C₁₆H₁₃BrN₄
• 分子量: 341.21
• InChiKey: HNVWZZKIHKMSPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.2
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-yl)hydrazine 、 水杨醛 在 gallium(III) trichloride 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 24.58h， 生成 Ga(KP1437)2Cl
  参考文献：
  名称：

  [DE] TUMORHEMMENDE ANNELLIERTE AZEPINONDERIVATE
  [EN] TUMOUR-INHIBITING ANNELLATED AZEPINONE DERIVATIVES
  [FR] DERIVES D'AZEPINONES CONDENSEES INHIBITEURS DE TUMEURS

  摘要：

  公开号：

  WO2004058766A3
• 作为产物：
  描述：

  9-bromo-6-(methylthio)-7,12-dihydroindolo[3,2-d][1]-benzazepine 在 肼 作用下， 以 乙醇 为溶剂， 反应 48.0h， 生成 (9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-yl)hydrazine
  参考文献：
  名称：

  Tumor-inhibiting anellated azepinone derivatives

  摘要：

  本发明涉及环化的氮杂七环酮衍生物、其制备方法、环化氮杂七环酮衍生物的金属配合物以及它们在治疗肿瘤疾病中的应用。

  公开号：

  US20060009445A1

文献信息

• Structure−Activity Relationships of Highly Cytotoxic Copper(II) Complexes with Modified Indolo[3,2-<i>c</i>]quinoline Ligands
  作者：Michael F. Primik、Simone Göschl、Michael A. Jakupec、Alexander Roller、Bernhard K. Keppler、Vladimir B. Arion

  DOI：10.1021/ic101633z

  日期：2010.12.6

  modified at the lactam unit to provide a peripheral binding site able to accommodate metal ions. Potentially tridentate ligands HL1a−HL4a and HL1b−HL4b were reacted with copper(II) chloride in isopropanol/methanol to give novel five-coordinate copper(II) complexes [Cu(HL1a−4a)Cl2] and [Cu(HL1b−4b)Cl2]. In addition, a new complex [Cu(HL5b)Cl2] and two previously reported compounds [Cu(HL6a)Cl2] and [Cu(HL6b)Cl2]

  在内酰胺单元上合成并修饰了许多吲哚并[3，2- c ]喹啉，以提供能够容纳金属离子的外围结合位点。潜在的三齿配体HL 1a - HL 4a和HL 1b - HL 4b与氯化铜（II）在异丙醇/甲醇中反应，得到新颖的五配位铜（II）配合物[Cu（HL 1a - 4a）Cl 2 ]和[ Cu（HL 1b - 4b）Cl 2 ]。此外，一种新的络合物[Cu（HL 5b）Cl 2]和两个以前报道的化合物[Cu（HL 6a）Cl 2 ]和[Cu（HL 6b）Cl 2 ]与修饰的paullone配体HL 5b，HL 6a和HL 6b，可以认为是吲哚喹啉HL 1b的相似物为了比较，合成了其中吡啶环被七元氮杂环庚环正式取代的HL，HL 4a和HL 4b。新的配体和铜（II）配合物的特征是1 H和13C NMR，IR和电子吸收光谱，ESI质谱，在298 K（[Cu（HL 1a）Cl 2 ]和[Cu（HL 4b）Cl
• Highly Cytotoxic Copper(II) Complexes with Modified Paullone Ligands
  作者：Michael F. Primik、Gerhard Mühlgassner、Michael A. Jakupec、Olivier Zava、Paul J. Dyson、Vladimir B. Arion、Bernhard K. Keppler

  DOI：10.1021/ic902042a

  日期：2010.1.4

  The reaction of copper(II) chloride or copper(II) acetate with 6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo-[3,2-d][1]benzazepine (HL1), 9-bromo-6-N-(2-N',N'-dimethylaminoethylamino)-7,12-dihydroindolo[3,2-d][1]-benzazepine (HL2), N-(9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-yliden-N'-(1-pyridin-2-yl-methylidene)azine (HL3), or N-(9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-yliden-N'-(1-pyridin-2-yl-ethylidene)azine (HL4) in methanol affords the novel copper(I-I) complexes [Cu(HL1)Cl-2] (1). [Cu(HL2)Cl-2] (2). [Cu(HL3)Cl-2] (3), [Cu(HL4)Cl-2] (4), and [Cu(L-4)(CH3COO)(CH3OH)] (5). The new ligands (HL2 and HL3) and the complexes 1-5 were characterized by H-1 and C-13 NMR, IR and electronic absorption spectroscopy, ESI mass spectrometry, and X-ray crystallography. Two ligands, HL1 and HL2, and complexes 1-4 were tested for cytotoxicity in three human cancer cell lines, namely, CH1 (ovarian carcinoma), A549 (non-small cell lung cancer), and SW480 (colon carcinoma). Additionally, complexes 1, 2, and 4 were assayed in an isogenic pair of ovarian cancer cell lines, one being sensitive to cisplatin (A2780) and the other having acquired cisplatin resistance (A2780cisR). All of the compounds evaluated are cytotoxic, with complexes 3 and 4 exhibiting IC50 values in the nanomolar range.
• Tumor-inhibiting anellated azepinone derivatives
  申请人：Keppler Bernhard

  公开号：US20060009445A1

  公开（公告）日：2006-01-12

  This invention relates to anellated azepinone derivatives, a method of their production, metal complexes of the anellated azepinone derivatives as well as their use in the treatment of tumor diseases.

  本发明涉及环化的氮杂七环酮衍生物、其制备方法、环化氮杂七环酮衍生物的金属配合物以及它们在治疗肿瘤疾病中的应用。
• [DE] TUMORHEMMENDE ANNELLIERTE AZEPINONDERIVATE<br/>[EN] TUMOUR-INHIBITING ANNELLATED AZEPINONE DERIVATIVES<br/>[FR] DERIVES D'AZEPINONES CONDENSEES INHIBITEURS DE TUMEURS
  申请人：FAUSTUS FORSCHUNGS CIE

  公开号：WO2004058766A3

  公开（公告）日：2004-08-26