N,N-diphenyllinoleamide | 10528-04-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N,N-diphenyllinoleamide
• 英文别名: Linolsaeure-N-phenylanilid；N-diphenyl linoleamide；(9Z,12Z)-N,N-diphenyloctadeca-9,12-dienamide
• CAS: 10528-04-8
• 化学式: C₃₀H₄₁NO
• 分子量: 431.662
• InChiKey: PZRRLJRVBGOESP-HZJYTTRNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.6
• 重原子数：
  32
• 可旋转键数：
  16
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• A METHOD OF TREATING PERIPHERAL INFLAMMATORY DISEASE
  申请人：Dublin City University

  公开号：EP3095444A1

  公开（公告）日：2016-11-23

  An active for use in the treatment or inhibition of an inflammatory disease associated with over-activation of Toll-like Receptor 4 (TLR4), Toll-like Receptor 2 (TLR2) and Myeloid differentiating protein 88 (Myd88) adaptor-like protein (Mal) while maintaining a subject's ability to respond normally to a pathogen, in which the active is an oleamide or a derivative thereof.

  一种用于治疗或抑制与Toll样受体4（TLR4）、Toll样受体2（TLR2）和髓样分化蛋白88（Myd88）适配样蛋白（Mal）过度激活相关的炎症性疾病，并同时保持受试者对病原体正常反应能力的活性物质为油酰胺或其衍生物。
• A METHOD FOR TREATING PERIPHERAL INFLAMMATORY DISEASE
  申请人：Dublin City University

  公开号：EP3297621A1

  公开（公告）日：2018-03-28
• [EN] A METHOD FOR TREATING PERIPHERAL INFLAMMATORY DISEASE<br/>[FR] PROCÉDÉ DE TRAITEMENT D'UNE MALADIE INFLAMMATOIRE PÉRIPHÉRIQUE
  申请人：UNIV DUBLIN CITY

  公开号：WO2016185025A1

  公开（公告）日：2016-11-24

  An active for use in the treatment or inhibition of an inflammatory disease associated with over- activation of Toll-like Receptor 4 (TLR4), Toll-like Receptor 2 (TLR2) and Myeloid differentiating protein 88 (Myd88) adaptor-like protein (Ma1) while maintaining a subject's ability to respond normally to a pathogen, in which the active is an oleamide or an immunomodulatory analogue thereof.