1,5-Pentandiylbis(diethylphosphan) | 82159-32-8

• 分子结构分类: 有机化合物 - 有机磷化合物 - 有机膦及其衍生物
• 英文名称: 1,5-Pentandiylbis(diethylphosphan)
• 英文别名: 1,5-Bis(diethylphosphino)pentane；3,9-diethyl-3,9-phosphaundecane；1,5-bis-diethylphosphino-pentane；Tetra-P-aethyl-P,P'-pentandiyl-di-phosphin；1,5-Bis-diaethylphosphino-pentan；Pentamethylen-bis-(diethylphosphin)；5-Diethylphosphanylpentyl(diethyl)phosphane
• CAS: 82159-32-8
• 化学式: C₁₃H₃₀P₂
• 分子量: 248.329
• InChiKey: FURQYMDAOWVTNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,5-Pentandiylbis(diethylphosphan) 在 fluorine 作用下， 以 various solvent(s) 为溶剂， 反应 12.0h， 生成 [5-[Difluoro-bis(1,1,2,2,2-pentafluoroethyl)-lambda5-phosphanyl]-1,1,2,2,3,3,4,4,5,5-decafluoropentyl]-difluoro-bis(1,1,2,2,2-pentafluoroethyl)-lambda5-phosphane
  参考文献：
  名称：

  Solution phase direct fluorination of bridged alkyl di- and triphosphines

  摘要：

  Perfluorinated phosphoranes with two phosphorus(V) centers have been prepared via elemental fluorination in solution. Oxidation sensitive a,w-bis(dialkylphosphino)alkanes are converted into the corresponding difluorophosphoranes. The F-19 and P-31 NMR are discussed. Additional characterization is provided by high and low resolution mass spectrometry. (C) 2000 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0022-1139(99)00298-5
• 作为产物：
  描述：

  1,5-二溴戊烷 、 二乙基磷化锂 生成 1,5-Pentandiylbis(diethylphosphan)
  参考文献：
  名称：

  CD4+ T-Lymphocytes Regulate Airway Remodeling and Hyper-Reactivity in a Mouse Model of Chronic Asthma

  摘要：

  Asthma is an acute-on-chronic inflammatory disease of the airways, characterized by airflow obstruction and hyper-reactivity of the airways to a variety of stimuli. Chronic asthma is associated with remodeling of the airway wall, which may contribute to hyper-reactivity and fixed airflow obstruction. We used an improved mouse model of chronic asthma to investigate the role of CD4(+) T-lymphocytes in airway remodeling and hyper-reactivity. Animals functionally depleted of CD4(+) T-lymphocytes by repeated administration of a monoclonal antibody exhibited markedly decreased airway responsiveness. In addition, these mice had greatly diminished subepithelial fibrosis, epithelial thickening, and mucous cell hyperplasia/metaplasia. Chronic inflammation in the airway wall was moderately reduced, with a marked decrease in the accumulation of immunoglobulin-synthesizing plasma cells. However, intraepithelial accumulation of eosinophils was not significantly inhibited and airway epithelial expression of eotaxin was undiminished. This work provides the first experimental evidence that CD4(+) T-lymphocytes play a crucial role in the pathogenesis of the lesions of chronic asthma and ends support to the notion that functional inhibition of these cells may be an important therapeutic target.

  DOI：

  10.1038/labinvest.3780438

文献信息

• Verfahren zur Herstellung von Aralkyl- und Alkyl-phenol-äthern
  申请人：BASF Aktiengesellschaft

  公开号：EP0000162A1

  公开（公告）日：1979-01-10

  Herstellung von Phenoläthern durch Umsetzung von Phenolen mit Dialkylcarbonaten in Gegenwart tertiärer Amine und/oder Phosphine. Die nach dem Verfahren der Erfindung herstellbaren Aralkylaryl- und Alkylaryläther sind wertovolle Ausgangsstoffe für die Herstellung von Farbstoffen, Pflanzenschutzmitteln und Riechstoffen.

  在叔胺和/或膦的存在下，通过苯酚与二烷基碳酸酯的反应生产苯酚醚。 通过本发明工艺生产的芳基和烷基芳基醚是生产染料、植物保护剂和香水的宝贵起始原料。
• Diemert, Klaus; Kuchen, Wilhelm; Kutter, Juergen, Chemische Berichte, 1982, vol. 115, # 5, p. 1947 - 1955
  作者：Diemert, Klaus、Kuchen, Wilhelm、Kutter, Juergen

  DOI：——

  日期：——
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ni: MVol.C2, 8.20, page 1073 - 1085
  作者：

  DOI：——

  日期：——
• Issleib,K. et al., Chemische Berichte, 1963, vol. 96, p. 2186 - 2192
  作者：Issleib,K. et al.

  DOI：——

  日期：——
• METHOD OF PRODUCING ALCOHOL
  申请人：Mitsubishi Chemical Corporation

  公开号：EP2221289B1

  公开（公告）日：2016-10-26