Aurigene 1 | 1673534-76-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Aurigene 1
• 英文别名: (2S,3R)-2-[[(1S)-3-amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]carbamoylamino]-3-hydroxybutanoic acid
• CAS: 1673534-76-3
• 化学式: C₁₂H₂₀N₆O₇
• 分子量: 360.32
• InChiKey: HFOBENSCBRZVSP-LKXGYXEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.7
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  227
• 氢给体数：
  7
• 氢受体数：
  10

文献信息

• Crystal forms of immunomodulators
  申请人：Curis, Inc.

  公开号：US11040948B2

  公开（公告）日：2021-06-22

  The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, including an anhydrous crystalline form, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.

  本发明涉及 3-取代的 1,2,4-噁二唑化合物的结晶形式（包括无水结晶形式）、其制备方法及其相关药物制剂。本发明还涉及适用于制药、兽医和农业相关用途的制剂。
• CRYSTAL FORMS OF IMMUNOMODULATORS
  申请人：Curis, Inc.

  公开号：US20200247766A1

  公开（公告）日：2020-08-06

  The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, including an anhydrous crystalline form, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.
• CONJOINT THERAPIES FOR IMMUNOMODULATION
  申请人：Aurigene Discovery Technologies Limited

  公开号：US20200289477A1

  公开（公告）日：2020-09-17

  The present disclosure relates to methods comprising administering compounds that inhibit VISTA and PD-1 (e.g., PD-1, PD-L1, or PD-L2) pathways with a compound that inhibits TIM-3 and PD-1 (e.g., PD-1, PD-L1, or PD-L2) pathways. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by VISTA, TIM-3, PD-1, PD-L1, and/or PD-L2.
• CRYSTALLINE FORMS OF 3-SUBSTITUTED 1,2,4- OXADIAZOLE
  申请人：Aurigene Discovery Technologies Limited

  公开号：US20220048875A1

  公开（公告）日：2022-02-17

  The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.
• [EN] CRYSTAL FORMS OF IMMUNOMODULATORS<br/>[FR] FORMES CRISTALLINES D'IMMUNOMODULATEURS
  申请人：CURIS INC

  公开号：WO2019067678A1

  公开（公告）日：2019-04-04

  The invention relates to crystalline forms of a 3-substituted 1,2,4-oxadiazole compound, including an anhydrous crystalline form, methods of their preparation, and related pharmaceutical preparations thereof. The invention also relates to preparations suitable for pharmaceutical, veterinary, and agriculturally-relevant uses.