(Z)-6-(2-((4-methoxy-1H,1'H-[2,2'-bipyrrol]-5-yl)-methylene)-3,5-dimethyl-2H-pyrrol-4-yl)hexan-1-ol | 1365480-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (Z)-6-(2-((4-methoxy-1H,1'H-[2,2'-bipyrrol]-5-yl)-methylene)-3,5-dimethyl-2H-pyrrol-4-yl)hexan-1-ol
• CAS: 1365480-79-0
• 化学式: C₂₂H₂₉N₃O₂
• 分子量: 367.491
• InChiKey: BDICCFLTAVQGAH-UYRXBGFRSA-N

反应信息

• 作为产物：
  描述：

  4,4-difluoro-1-methoxy-3-pyrrolyl-5,7-dimethyl-6-(hexan-1-ol)-2,8-H-4-bora-3a,4a-diaza-s-indacene 在 水 、 potassium hydroxide 、 叔丁醇 作用下， 反应 0.25h， 以94%的产率得到(Z)-6-(2-((4-methoxy-1H,1'H-[2,2'-bipyrrol]-5-yl)-methylene)-3,5-dimethyl-2H-pyrrol-4-yl)hexan-1-ol
  参考文献：
  名称：

  Use of F-BODIPYs as a Protection Strategy for Dipyrrins: Optimization of BF₂ Removal

  摘要：

  We recently reported the first general method for the deprotection of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacenes (F-BODIPYs) involving a microwave-assisted procedure for the removal of the BF2 moiety, and liberation of the corresponding free-base dipyrrin. Further optimization of the reaction has resulted in a more convenient and accessible protocol. The availability of this new methodology enables BF2-complexation to be used as a dipyrrin protection strategy. Herein lies a detailed examination of the deprotection reaction, with a view to optimization and gaining mechanistic insight, and its application in facilitating a multistep synthesis of pyrrolyldipyrrins.

  DOI：

  10.1021/jo3002003