(Z)-2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine | 221907-21-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine
• 英文别名: (Z)-2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(4-methylphenyl)ethenamine
• CAS: 221907-21-7
• 化学式: C₁₂H₁₄N₂S
• 分子量: 218.323
• InChiKey: YGUPCQOBSWHFRD-FLIBITNWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  15.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.38
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-碘代丙烷 、 (Z)-2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine 在 正丁基锂 作用下， 生成 (Z)-2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(4-methylphenyl)-1-pentene-1-amine
  参考文献：
  名称：

  Synthesis and C-alkylation of C-protected β-enamino acid derivatives from oxa- thia- and imidazolines

  摘要：

  Various heterocycles 3a-h can be readily metallated and condensed with a variety of organic nitriles to afford C-protected beta-enamino acid derivatives 1 (or 2). Procedures for alkylation of compounds 1 to obtain 2 as well as a "one-pot" preparation of 2 from 3 are also described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00042-3
• 作为产物：
  描述：

  2-甲基-2-噻唑啉 、 对甲苯腈 在 正丁基锂 作用下， 生成 (Z)-2-(4,5-dihydro-1,3-thiazol-2-yl)-1-(4-methylphenyl)-1-ethen-1-amine
  参考文献：
  名称：

  Synthesis and C-alkylation of C-protected β-enamino acid derivatives from oxa- thia- and imidazolines

  摘要：

  Various heterocycles 3a-h can be readily metallated and condensed with a variety of organic nitriles to afford C-protected beta-enamino acid derivatives 1 (or 2). Procedures for alkylation of compounds 1 to obtain 2 as well as a "one-pot" preparation of 2 from 3 are also described. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(99)00042-3