1,4,5,6,7,8-Hexahydrocyclohepta[b]pyrrole-2-carboxylic acid | 1403469-24-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1,4,5,6,7,8-Hexahydrocyclohepta[b]pyrrole-2-carboxylic acid
• CAS: 1403469-24-8
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.22
• InChiKey: HOXGIMJQLBASEM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] NEW THERAPEUTIC AGENTS FOR THE TREATMENT OF HAEMATOLOGICAL PATHOLOGIES<br/>[FR] NOUVEAUX AGENTS THÉRAPEUTIQUES POUR LE TRAITEMENT DE PATHOLOGIES HÉMATOLOGIQUES
  申请人：UNIV DEGLI STUDI DI PALERMO

  公开号：WO2021038452A1

  公开（公告）日：2021-03-04

  The present invention relates to compounds having a tetracyclic system and the use thereof as new therapeutic agents in the treatment of acute myeloid leukemia (AML), preferably in FLT3/ITD hemizygote patients resistant to conventional therapies. The invention also relates to 5,7-dihydro-4H-[1,3]thiazolo[4,5-e]isoindol-2-amine compounds useful as intermediates for the synthesis of tetracyclic imidazo[2',1':2,3][1,3]thiazolo[4,5-e]isoindole compounds.

  该发明涉及具有四环系统的化合物及其作为新的治疗剂在治疗急性髓样白血病（AML）中的用途，优选用于对传统疗法具有抗药性的FLT3/ITD半合子患者。该发明还涉及5,7-二氢-4H-[1,3]噻唑并[4,5-e]异吲哚-2-胺化合物，可用作合成四环咪唑并[2',1':2,3][1,3]噻唑并[4,5-e]异吲哚化合物的中间体。
• INHIBITORS OF D-AMINO ACID OXIDASE
  申请人：Heffernan Michele L. R.

  公开号：US20100029737A1

  公开（公告）日：2010-02-04

  The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatric diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia.

  本发明提供了新型D-氨基酸氧化酶酶的抑制剂。本发明的化合物可用于治疗或预防疾病和/或症状，其中调节D-丝氨酸水平和/或其氧化产物对缓解症状有效。本发明还提供了增强学习，记忆和/或认知的方法。例如，本发明提供了用于治疗或预防神经退行性疾病（如阿尔茨海默病）相关的记忆和/或认知丧失的方法。本发明还提供了预防神经退行性疾病特征性神经元功能丧失的方法。此外，还提供了用于治疗或预防神经精神疾病（例如，精神分裂症）和用于治疗或预防疼痛和共济失调的方法。
• NEW THERAPEUTIC AGENTS FOR THE TREATMENT OF HAEMATOLOGICAL PATHOLOGIES
  申请人：Universita' degli Studi di Palermo

  公开号：EP4021910A1

  公开（公告）日：2022-07-06
• US7902252B2
  申请人：——

  公开号：US7902252B2

  公开（公告）日：2011-03-08
• [EN] INHIBITORS OF D-AMINO ACID OXIDASE<br/>[FR] INHIBITEURS DE LA D-AMINO ACIDE OXYDASE
  申请人：SEPRACOR INC

  公开号：WO2008089453A2

  公开（公告）日：2008-07-24

  (EN) The present invention provides novel inhibitors of the enzyme D- amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/ or conditions, wherein modulation of D- serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatry diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia.(FR) La présente invention concerne de nouveaux inhibiteurs de l'enzyme D-amino acide oxydase. Les composés de l'invention sont utiles pour le traitement ou la prévention de maladies et/ou d'affection, où la modulation de niveaux de D-sérine et/ou ces produits oxydatifs est efficace pour l'amélioration des symptômes. L'invention concerne en outre des procédés d'amélioration de l'apprentissage, de la mémoire et/ou de la commission. A titre d'exemple, l'invention propose des procédés pour le traitement ou la prévention de la perte de mémoire et/ou de la cognition associés à des maladies neurodégénératives, telles que la maladie d'Alzheimer. L'invention propose en outre des procédés pour la prévention de la perte de fonction neuronale caractéristique de maladies neurodégénératives. De plus, des procédés sont prévus pour le traitement et la prévention de maladies neuropsychiatriques (par exemple, schizophrénie) et pour le traitement ou la prévention de la douleur et de l'ataxie.