1-Methyl-3-[6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazin-2-yl]urea | 1191891-92-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-Methyl-3-[6-(4-methylsulfonylphenyl)imidazo[1,2-b]pyridazin-2-yl]urea
• CAS: 1191891-92-5
• 化学式: C₁₅H₁₅N₅O₃S
• 分子量: 345.382
• InChiKey: RBDFXQWGLCJLNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  114
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• HETEROCYCLIC COMPOUND HAVING INHIBITORY ACTIVITY ON PI3K
  申请人：Taniyama Daisuke

  公开号：US20110105457A1

  公开（公告）日：2011-05-05

  The purpose of the present invention is to provide a compound or a pharmaceutically acceptable salt thereof which inhibits the activity of PI3K to regulate many biological processes including the growth, differentiation, survival, proliferation, migration, metabolism, and the like of cells and is therefore useful for the prevention/treatment of diseases including inflammatory diseases, arteriosclerosis, vascular/circulatory diseases, cancer/tumors, immune system diseases, cell proliferative diseases, infectious diseases, and the like. This was achieved by providing a substituted 2-amino-5,6-nitrogenated fused ring compound shown in the present specification, or a pharmaceutically acceptable salt thereof.