4-(1,3-Dimethylpyrazol-5-ylcarbonylaminomethyl)-phenol | 55458-71-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-(1,3-Dimethylpyrazol-5-ylcarbonylaminomethyl)-phenol
• 英文别名: 2,5-dimethyl-2H-pyrazole-3-carboxylic acid 4-hydroxy-benzylamide；N-[(4-hydroxyphenyl)methyl]-2,5-dimethylpyrazole-3-carboxamide
• CAS: 55458-71-4
• 化学式: C₁₃H₁₅N₃O₂
• mdl: MFCD26971848
• 分子量: 245.281
• InChiKey: XBSWUTROIITYPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  67.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Pyrazole derivative, insecticidal or miticidal composition containing the same as the effective ingredient
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0289879A1

  公开（公告）日：1988-11-09

  A novel pyrazole derivative and an insecticidal or miticidal composition containing the derivative as the effective ingredient are disclosed. The pyrazole derivative of the present invention has an excellent controlling effect also against harmful insects and mites exhibiting resistance to conventional insecticides and does not disturb the ecosystem since it is less toxic and less residual.

  本发明公开了一种新型吡唑衍生物和一种含有该衍生物作为有效成分的杀虫或杀螨剂组合物。 本发明的吡唑衍生物对对传统杀虫剂有抗药性的有害昆虫和螨虫也有很好的防治效果，而且由于毒性低、残留少，不会扰乱生态系统。
• Pyrazole derivative and insecticidal and miticidal composition containing the derivative as active ingredient
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0307801A1

  公开（公告）日：1989-03-22

  A pyrazole derivative represented by the following formula (I): wherein R and R1 independently represent a hydrogen atom or a C1-C4 alkyl group; R2 represents a hydrogen atom, a C1-C4 alkyl group, a phenyl group or a benzyl group, which bonds to one of the nitrogen atoms of the pyrazole ring; R3 and R4 independently represent a hydrogen atom, a C1-C4 alkyl group or a phenyl group; R5 and R6 independently represent a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a C1-C4 alkoxy group, a C1-C4 halogenoalkoxy group,a C1-C4 hydroxyalkoxy group, a C2-C7 alkoxyalkoxy group, a nitro group, a trifluoromethyl group, a phenyl group, a phenoxy group, a benzyloxy group, an amino group, a C1-C4 alkylamino group, a C2-C8 dialkylamino group, a cyano group, a carboxyl group, a C2-C5 alkoxycarbonyl group, a C4-C7 cycloalkoxycarbonyl group, a C3-C9 alkoxyalkoxycarbonyl group, a C2-C7 alkylaminocarbonyl group, a C3-C11 dialkylaminocarbonyl group, a piperidinocarbonyl group, a morpholinocarbonyl group, a trimethylsilyl group, a C1-C4 alkylthio group, a C1-C4 alkylsulfinyl group or a C1-C4 alkylsulfonyl group; " X represents an oxygen atom, a sulfur atom, NHO or NR7 wherein R7 represents a hydrogen atom or a C1-C4 alkyl group; Y represents an oxygen atom or a sulfur atom; m represents 1 or 2; and n represents 0 or 1, and an insecticidal or miticidal composition containing the derivative as the effective ingredient are disclosed. The pyrazole derivative of the present invention has an excellent controlling effect also against harmful insects and mites exhibiting resistance to conventional insecticides and does not disturb the ecosystem since it is less toxic and less residual.

  由下式(I)代表的吡唑衍生物： 其中 R 和 R1 独立地代表氢原子或 C1-C4 烷基；R2 代表氢原子、C1-C4 烷基、苯基或苄基，它们与吡唑环的一个氮原子结合；R3 和 R4 独立地代表氢原子、C1-C4 烷基或苯基；R5和R6各自代表氢原子、卤素原子、C1-C6烷基、C3-C6环烷基、C1-C4烷氧基、C1-C4卤代烷氧基、C1-C4羟基烷氧基、C2-C7烷氧基烷氧基、硝基、三氟甲基、苯基、苯氧基、苄氧基、氨基、C1-C4烷基氨基、C2-C8二烷基氨基、氰基、羧基、C2-C5 烷氧基羰基、C4-C7 环烷氧基羰基、C3-C9 烷氧基羰基、C2-C7 烷基氨基羰基、C3-C11 二烷基氨基羰基、哌啶基羰基、吗啉基羰基、三甲基硅基、C1-C4 烷硫基、C1-C4 烷基亚磺酰基或 C1-C4 烷基磺酰基；"X代表氧原子、硫原子、NHO或NR7，其中R7代表氢原子或C1-C4烷基；Y代表氧原子或硫原子；m代表1或2；n代表0或1，本发明公开了含有该衍生物作为有效成分的杀虫或杀螨剂组合物。 本发明的吡唑衍生物对传统杀虫剂具有抗性的有害昆虫和螨虫也有很好的防治效果，而且由于其毒性低、残留少，不会扰乱生态系统。
• Pyrazole derivatives, processes for their manufacture and insecticidal, miticidal and fungicidal compositions containg the derivatives as active ingredients
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0329020A1

  公开（公告）日：1989-08-23

  Disclosed herein are pyrazole derivatives which are represented by the following formula (I): wherein R1 represents a C1-C4- alkyl group or a benzyl group; R2 represents a hydrogen atom or a C1-C4- alkyl group; X represents a hydrogen atom, a halogen atom or a C1-C4- alkyl group; R2 may combine with X to form wherein R5 represents a hydrogen atom or a C1-C3 alkyl group; R3 represents a hydrogen atom or a C1-C4- alkyl group; R4s independently represent a hydrogen atom, a halogen atom, a C1-CS alkyl group, a C1-C4- alkoxy group, a C1-C4- alkylthio group, a trifluoromethyl group, a C1-C4- haloalkoxy group, a phenyl group, an alkyl-substituted phenyl group or wherein Y represents an oxygen atom or a sulfur atom, R6s independently represent a hydrogen atom, a C1-C4 alkyl group, a C1-C4- alkoxy group, a halogen atom, a nitro group, a cyano group or a trifluoromethyl group and n represents 1 or 2, adjacent R4s being able to combine together to form wherein R7 represents a hydrogen atom or a methyl group; ℓ represents 0 or 1; and m represents 1, 2 or 3. The pyrazole derivatives of the formula (I) show a high activity suitable for active ingredient of insecticidal and miticidal composition as well as fungicidal composition.

  本文公开的吡唑衍生物由下式(I)表示： 其中 R1 代表 C1-C4- 烷基或苄基； R2 代表氢原子或 C1-C4- 烷基； X 代表氢原子、卤素原子或 C1-C4- 烷基； R2 可与 X 结合形成 其中 R5 代表氢原子或 C1-C3 烷基； R3 代表氢原子或 C1-C4- 烷基； R4s 独立地代表氢原子、卤素原子、C1-CS 烷基、C1-C4-烷氧基、C1-C4-烷硫基、三氟甲基、C1-C4-卤代烷氧基、苯基、烷基取代的苯基或 其中 Y 代表氧原子或硫原子，R6s 独立地代表氢原子、C1-C4-烷基、C1-C4-烷氧基、卤素原子、硝基、氰基或三氟甲基，n 代表 1 或 2，相邻的 R4s 可结合在一起形成 其中 R7 代表氢原子或甲基；ℓ 代表 0 或 1；m 代表 1、2 或 3。 式（I）的吡唑衍生物具有很高的活性，适合作为杀虫、杀螨剂和杀真菌剂的活性成分。
• Pyrazole amides and insecticide and miticide containing them as active ingredient
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0365925A1

  公开（公告）日：1990-05-02

  Pyrazole amide represented by the following formula (I): where R¹ represents alkyl; R² represents hydrogen atom, alkyl, cyclopropyl, alkoxy or alkylcarbonyloxy; X represents hydrogen, halogen, alkyl, alkoxy, haloalkoxy, alkylcarbonyloxy group or hydroxy group; R² and X may combine together to form in which R⁹ represents hydrogen or alkyl; one of R³, R⁴ and R⁵ is hydrogen and the others represent independently hydrogen, halogen, alkyl, haloalkyl, cycloalkyl, alkoxy, haloalkoxy, amino, alkylamino, dialkylamino, alkoxy­ carbonylamino, alkylthio, alkylsulfinyl, alkylsulfonyl, alkoxycarbonyl, alkylcarbonyl, nitro, cyano, hydroxymethyl, alkoxyalkyl or alkoxyalkoxyalkyl; R³ and R⁴ may combine together to form in which R¹⁰ and R¹¹ represent independently hydrogen or alkyl; one of R⁶ and R⁷ represents hydrogen and the other represents hydrogen, alkyl, alkoxy or halogen; Y represents oxygen, sulfur, sulfinyl, sulfonyl or carbonyl; B represents -CH- or nitrogen; R⁸ represents hydrogen or methyl and Z represents oxygen or sulfur, with the proviso that all of R³, R⁴ and R⁵ are not hydrogen atoms when Y is oxygen and B is -CH-, and an insecticidal and miticidal composition containing the pyrazole amide as an active ingredient are described. The pyrazole amide according to the present invention shows excellent insecticidal and miticidal activities.

  下式(I)所代表的吡唑酰胺： 其中 R¹ 代表烷基；R² 代表氢原子、烷基、环丙基、烷氧基或烷基羰基氧基；X 代表氢、卤素、烷基、烷氧基、卤代烷氧基、烷基羰基氧基或羟基；R² 和 X 可结合在一起形成 其中 R⁹ 代表氢或烷基；R³、R⁴ 和 R⁵ 中的一个为氢，其他独立地代表氢、卤素、烷基、卤代烷基、环烷基、烷氧基、卤代烷氧基、氨基、烷基氨基、二烷基氨基、烷氧基羰基氨基、烷硫基、烷基亚磺酰基、烷基磺酰基、烷氧基羰基、烷基羰基、硝基、氰基、羟甲基、烷氧基烷基或烷氧基烷氧基烷基；R³ 和 R⁴ 可结合在一起形成 其中 R¹⁰ 和 R¹¹ 独立地代表氢或烷基；R⁶ 和 R⁷ 中的一个代表氢，另一个代表氢、烷基、烷氧基或卤素；Y 代表氧、硫、亚砜基、磺酰基或羰基；B 代表-CH- 或氮；R⁸ 代表氢或甲基，Z 代表氧或硫，但当 Y 为氧和 B 为 -CH- 时，所有 R³、R⁴ 和 R⁵ 都不是氢原子。 本发明的吡唑酰胺具有优异的杀虫和杀螨活性。
• US4861777A
  申请人：——

  公开号：US4861777A

  公开（公告）日：1989-08-29