N1-(2-aminoethyl)-2,2-dimethyl-N1,N3-bis(pyridin-2-ylmethyl)propane-1,3-diamine | 1310358-61-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N1-(2-aminoethyl)-2,2-dimethyl-N1,N3-bis(pyridin-2-ylmethyl)propane-1,3-diamine
• 英文别名: 3,7-bis(2-pyridylmethyl)-5,5-dimethyl-3,7-diazaheptane-1-amine；3,7-Bis(2-pyridylmethyl)-5,5-dimethyl-3,7-diazaheptane-1-amine；N-(2-aminoethyl)-2,2-dimethyl-N,N'-bis(pyridin-2-ylmethyl)propane-1,3-diamine
• CAS: 1310358-61-2
• 化学式: C₁₉H₂₉N₅
• 分子量: 327.473
• InChiKey: SCYYGDUHYRXKPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  24
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  67.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  吡啶-2-甲醛 、 N1-(2-aminoethyl)-2,2-dimethyl-N1,N3-bis(pyridin-2-ylmethyl)propane-1,3-diamine 、 sodium perchlorate 以 甲醇 为溶剂， 以77%的产率得到
  参考文献：
  名称：

  Synthesis and characterization of two new asymmetrical branched amines and related Mn(II) and Ni(II) Schiff base complexes containing pyridine moieties: Crystal structures of Mn(II) and Ni(II) complexes and their antibacterial properties

  摘要：

  Two new branched pentadentate amines (N-5), 3,7-bis(2-pyridylmethyl)-5,5-dimethyl-3,7-diazaheptane-1-amine (1) and 4,8-bis(2-pyridylmethyl)-6,6-dimethyl-4,8-diaza octane-1-amine (2) have been prepared. These have been used to synthesis two new Schiff base complexes containing a pyridine and 2-pyridylmethyl pendant arm, by template [1+1] condensation of pyridine-2-carbaldehyde with the amines in the presence of Mn(II) in methanol. Elemental and spectral results are used to characterize the complexes and their structures are confirmed by single crystal X-ray diffraction studies. The structure of MnL1(ClO4)(2) indicates that in the solid state the Mn(II) ion adopts a slightly distorted octahedral geometry. The crystal structure of [Ni(1)(MeCN)](ClO4)(2) is also reported and exhibits a slightly distorted octahedral geometry. Also the synthesized complexes were screened for their antibacterial activity against Escherichia colt (Lio), Serratia marcescens (PTCC 1330), Staphylococcous aureus (ATCC 6633), and Proteus vulgaris (Lio) and results showed that the all complexes have antibacterial effects and [NiL1](ClO4)(2). [NiL1](ClO4)(2), [MnL2](ClO4) and [MnL1](ClO4)(2) have more effective ones against E. coli. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.04.039
• 作为产物：
  描述：

  2,2-dimethyl-N,N'-bis(pyridin-2-ylmethyl)propane-1,3-diamine 在 硫酸 作用下， 以 乙腈 为溶剂， 反应 78.0h， 生成 N1-(2-aminoethyl)-2,2-dimethyl-N1,N3-bis(pyridin-2-ylmethyl)propane-1,3-diamine
  参考文献：
  名称：

  两种新型吡啶基-脂族胺配体的铜（ii）配合物：合成，结构，EPR和磁性研究*

  摘要：

  已经制备了两个新的多胺配体L 1和L 2，它们结合了吡啶基和脂肪族胺供体，它们与铜（ii）的反应生成了单核和双核配合物[Cu（L 1）]（ClO 4）2（1）和[Cl 2 Cu（L 2）CuCl（H 2 O）] ClO 4（2）。的X射线结构1所证实，五个氮供体大号1与中心铜离子结合形成扭曲的方形锥体配位球。在2，大号2只充当带有其N桥接配体3端供体配位结构域分离由米-xylylene间隔基团。后一种配合物的一个不寻常的特征是，对称的L 2会在各个铜位上产生非等价的配位行为。虽然两个站点在扭曲的方形金字塔形排列上均显示五坐标，但它们的区别在于N 3 Cl 2-和N 3ClO-供体原子组。讨论了两种配合物的电子顺磁共振（EPR）光谱。可变温度磁化率数据证实了不存在磁相互作用的在1而铜（之间的弱的反铁磁相互作用II）中心中出现2。

  DOI：

  10.1071/ch12145

文献信息

• Synthesis and characterization of two new asymmetrical branched amines and related Mn(II) and Ni(II) Schiff base complexes containing pyridine moieties: Crystal structures of Mn(II) and Ni(II) complexes and their antibacterial properties
  作者：Hassan Keypour、Musa Ahmadi、Majid Rezaeivala、Abdolkarim Chehregani、Reza Golbedaghi、Allan G. Blackman

  DOI：10.1016/j.poly.2011.04.039

  日期：2011.6

  Two new branched pentadentate amines (N-5), 3,7-bis(2-pyridylmethyl)-5,5-dimethyl-3,7-diazaheptane-1-amine (1) and 4,8-bis(2-pyridylmethyl)-6,6-dimethyl-4,8-diaza octane-1-amine (2) have been prepared. These have been used to synthesis two new Schiff base complexes containing a pyridine and 2-pyridylmethyl pendant arm, by template [1+1] condensation of pyridine-2-carbaldehyde with the amines in the presence of Mn(II) in methanol. Elemental and spectral results are used to characterize the complexes and their structures are confirmed by single crystal X-ray diffraction studies. The structure of MnL1(ClO4)(2) indicates that in the solid state the Mn(II) ion adopts a slightly distorted octahedral geometry. The crystal structure of [Ni(1)(MeCN)](ClO4)(2) is also reported and exhibits a slightly distorted octahedral geometry. Also the synthesized complexes were screened for their antibacterial activity against Escherichia colt (Lio), Serratia marcescens (PTCC 1330), Staphylococcous aureus (ATCC 6633), and Proteus vulgaris (Lio) and results showed that the all complexes have antibacterial effects and [NiL1](ClO4)(2). [NiL1](ClO4)(2), [MnL2](ClO4) and [MnL1](ClO4)(2) have more effective ones against E. coli. (C) 2011 Elsevier Ltd. All rights reserved.
• Copper(II) Complexes of Two New Pyridyl–Aliphatic Amine Ligands: Synthetic, Structural, EPR, and Magnetic Studies
  作者：Young Hoon Lee、Hari Kristopo、Arim Woo、Mi Seon Won、Shinya Hayami、Pierre Thuéry、Ok-Sang Jung、Hong In Lee、Bok Jo Kim、Leonard F. Lindoy、Yang Kim

  DOI：10.1071/ch12145

  日期：——

  latter complex is that symmetrical L2 gives rise to non-equivalent coordination behaviour at the individual copper sites; while both sites display five-coordination with distorted square pyramidal arrangements, they differ in having N3Cl2- and N3ClO-donor atom sets, respectively. The electron paramagnetic resonance (EPR) spectra of both complexes are discussed. Variable temperature magnetic susceptibility

  已经制备了两个新的多胺配体L 1和L 2，它们结合了吡啶基和脂肪族胺供体，它们与铜（ii）的反应生成了单核和双核配合物[Cu（L 1）]（ClO 4）2（1）和[Cl 2 Cu（L 2）CuCl（H 2 O）] ClO 4（2）。的X射线结构1所证实，五个氮供体大号1与中心铜离子结合形成扭曲的方形锥体配位球。在2，大号2只充当带有其N桥接配体3端供体配位结构域分离由米-xylylene间隔基团。后一种配合物的一个不寻常的特征是，对称的L 2会在各个铜位上产生非等价的配位行为。虽然两个站点在扭曲的方形金字塔形排列上均显示五坐标，但它们的区别在于N 3 Cl 2-和N 3ClO-供体原子组。讨论了两种配合物的电子顺磁共振（EPR）光谱。可变温度磁化率数据证实了不存在磁相互作用的在1而铜（之间的弱的反铁磁相互作用II）中心中出现2。