2-dimethylaminomethylene-5-(2-methoxy-phenyl)-cyclohexane-1,3-dione | 1083067-08-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-dimethylaminomethylene-5-(2-methoxy-phenyl)-cyclohexane-1,3-dione
• CAS: 1083067-08-6
• 化学式: C₁₆H₁₉NO₃
• 分子量: 273.332
• InChiKey: UCHLDYRNDOHPIG-RAXLEYEMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.16
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.61
• 氢给体数：
  0.0
• 氢受体数：
  4.0

文献信息

• USE OF AMINOMETHYLENECYCLOHEXANE-1,3-DIONE COMPOUND
  申请人：WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.

  公开号：US20200170966A1

  公开（公告）日：2020-06-04

  The present invention relates to use of an aminomethylenecyclohexane-1,3-dione compound, more particularly to use of a compound shown in the following formula (I) or a pharmaceutically acceptable salt thereof alone or in combination with other drug in preparing a drug for regulating or treating a disease related to autophagy, especially mammalian ATG8 homologous proteins.

  本发明涉及使用氨甲基环己烷-1,3-二酮化合物，更具体地涉及使用以下式（I）所示的化合物或其药学上可接受的盐单独或与其他药物结合，用于制备用于调节或治疗与自噬相关的疾病，特别是哺乳动物ATG8同源蛋白的药物。
• QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS
  申请人：Courtney Stephen Martin

  公开号：US20110118258A1

  公开（公告）日：2011-05-19

  Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.

  通式（I）的化合物；或其立体异构体、互变异构体、药学上可接受的盐或前药，其中R1、R2、R3、R4、R5、R6、R8和R9如本文所定义，对于治疗由过度或不恰当的Hsp90活性介导的疾病和病况，如癌症、病毒感染和炎症性疾病或病况，是有用的。
• Use of aminomethylenecyclohexane-1,3-dione compound
  申请人：WIGEN BIOMEDICINE TECHNOLOGY (SHANGHAI) CO., LTD.

  公开号：US11529321B2

  公开（公告）日：2022-12-20

  The present invention relates to use of an aminomethylenecyclohexane-1,3-dione compound, more particularly to use of a compound shown in the following formula (I) or a pharmaceutically acceptable salt thereof alone or in combination with other drug in preparing a drug for regulating or treating a disease related to autophagy, especially mammalian ATG8 homologous proteins.

  本发明涉及氨甲基环己烷-1,3-二酮化合物的用途，更具体地说，涉及下式(I)所示化合物或其药学上可接受的盐单独或与其他药物组合用于制备调节或治疗与自噬有关的疾病，特别是哺乳动物ATG8同源蛋白的药物。
• US8592430B2
  申请人：——

  公开号：US8592430B2

  公开（公告）日：2013-11-26
• [EN] QUINAZOLIN-OXIME DERIVATIVES AS HSP90 INHIBITORS<br/>[FR] DÉRIVÉS D'OXIME QUINAZOLINE INHIBITEURS DES HSP90
  申请人：DAC SRL

  公开号：WO2008142720A2

  公开（公告）日：2008-11-27

  (EN) Compounds of general formula (I); or a stereoisomers, tautomers, pharmaceutically acceptable salts, or prodrugs thereof, wherein R1, R2, R3, R4, R5, R6, R8 and R9 are as defined herein, are useful for the treatment of diseases and conditions which are mediated by excessive or inappropriate Hsp90 activity such as cancers, viral infection and inflammatory diseases or conditions.(FR) La présente invention concerne les composés de formule générale (I), ou des stéréoisomères, tautomères, sels pharmaceutiquement acceptables ou prodrogues de ceux-ci, où R1, R2, R3, R4, R5, R6, R8 et R9 sont comme définis dans la présente, sont utiles pour le traitement de maladies et de conditions causées par une activité excessive ou inappropriée des Hsp90 telles que les cancers, les infections virales et les maladies et conditions inflammatoires.