5-(2-phthalimidoethoxy)-isophthalic acid dimethyl ester | 198700-42-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-phthalimidoethoxy)-isophthalic acid dimethyl ester
• 英文别名: Dimethyl 5-[2-(1,3-dioxoisoindol-2-yl)ethoxy]benzene-1,3-dicarboxylate
• CAS: 198700-42-4
• 化学式: C₂₀H₁₇NO₇
• 分子量: 383.357
• InChiKey: LNKDYENSSUELCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  99.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-(2-phthalimidoethoxy)-isophthalic acid dimethyl ester 在 盐酸 、 sodium hydroxide 、 一水合肼 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 5.0h， 生成 5-((-2-((tert-butyloxy)carbonyl)amino)ethoxy)benzene-1,3-dicarboxylic acid
  参考文献：
  名称：

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid

  摘要：

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid have been synthesized up to generation 4 following the convergent approach. This involved a repetitive reaction of 5-(2-t-butoxycarbamylethoxy)-isophthalic acid with the two fold excess of 5-(2-aminoethoxy-hydrochloride)-isophthalic acid dimethyl ester and its analogs of higher generation, respectively, using activation and protection methods from the peptide chemistry. The products were characterized via elemental analysis, different spectroscopic methods, gel permeation chromatograpy, and differential scanning calorimetry. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00978-2
• 作为产物：
  描述：

  N-羟乙基酞酰亚胺 、 5-羟基间苯二甲酸二甲酯 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 48.0h， 以88%的产率得到5-(2-phthalimidoethoxy)-isophthalic acid dimethyl ester
  参考文献：
  名称：

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid

  摘要：

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid have been synthesized up to generation 4 following the convergent approach. This involved a repetitive reaction of 5-(2-t-butoxycarbamylethoxy)-isophthalic acid with the two fold excess of 5-(2-aminoethoxy-hydrochloride)-isophthalic acid dimethyl ester and its analogs of higher generation, respectively, using activation and protection methods from the peptide chemistry. The products were characterized via elemental analysis, different spectroscopic methods, gel permeation chromatograpy, and differential scanning calorimetry. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00978-2

文献信息

• Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid
  作者：Brigitte I. Voit、Dieter Wolf

  DOI：10.1016/s0040-4020(97)00978-2

  日期：1997.11

  Perfectly branched polyamide dendrons based on 5-(2-aminoethoxy)-isophthalic acid have been synthesized up to generation 4 following the convergent approach. This involved a repetitive reaction of 5-(2-t-butoxycarbamylethoxy)-isophthalic acid with the two fold excess of 5-(2-aminoethoxy-hydrochloride)-isophthalic acid dimethyl ester and its analogs of higher generation, respectively, using activation and protection methods from the peptide chemistry. The products were characterized via elemental analysis, different spectroscopic methods, gel permeation chromatograpy, and differential scanning calorimetry. (C) 1997 Elsevier Science Ltd.