1-(diphenethylphosphoryl)-3-(trimethylsilyl)-2-propyn-1-ol | 500599-21-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(diphenethylphosphoryl)-3-(trimethylsilyl)-2-propyn-1-ol
• 英文别名: 2-Propyn-1-ol, 1-[bis(2-phenylethyl)phosphinyl]-3-(trimethylsilyl)-；1-[bis(2-phenylethyl)phosphoryl]-3-trimethylsilylprop-2-yn-1-ol
• CAS: 500599-21-3
• 化学式: C₂₂H₂₉O₂PSi
• 分子量: 384.53
• InChiKey: VSEFXJHSXOPCMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.03
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-三甲基甲硅烷基丙炔醛 、 bis(2-phenylethyl)phosphine oxide 以 四氢呋喃 为溶剂， 反应 1.33h， 以98%的产率得到1-(diphenethylphosphoryl)-3-(trimethylsilyl)-2-propyn-1-ol
  参考文献：
  名称：

  Regioselective addition of secondary phosphine oxides to 3-(trialkylsilyl)- and 3-(trialkylgermyl)-2-propynals

  摘要：

  3-(Trialkylsilyl)- and 3-(trialkylgermyl)-2-propynals as well as 2-propynal react with secondary phosphine oxides by carbonyl group under mild conditions (-10 to 22 degreesC) to give corresponding tertiary phosphine oxides with acetylenic and hydroxyl moieties in quantitative yield. The reactivity of the aldehydes in this reaction drops in the following order: HGdropCC(O)H > Me(3)SiCdropCC(O)H > Et(3)GeCdropCC(O)H. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(02)01724-2

文献信息

• Regioselective addition of secondary phosphine oxides to 3-(trialkylsilyl)- and 3-(trialkylgermyl)-2-propynals
  作者：Nina K Gusarova、Aelita M Reutskaya、Nina I Ivanova、Alevtina S Medvedeva、Maria M Demina、Peter S Novopashin、Andrei V Afonin、Alexander I Albanov、Boris A Trofimov

  DOI：10.1016/s0022-328x(02)01724-2

  日期：2002.10

  3-(Trialkylsilyl)- and 3-(trialkylgermyl)-2-propynals as well as 2-propynal react with secondary phosphine oxides by carbonyl group under mild conditions (-10 to 22 degreesC) to give corresponding tertiary phosphine oxides with acetylenic and hydroxyl moieties in quantitative yield. The reactivity of the aldehydes in this reaction drops in the following order: HGdropCC(O)H > Me(3)SiCdropCC(O)H > Et(3)GeCdropCC(O)H. (C) 2002 Elsevier Science B.V. All rights reserved.