N-((1S)-1-((1R)-2-(((1R,2R,4'S)-6'-(2,2-dimethylpropyl)-2-hydroxy-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-buten-1-yl)acetamide | 1091623-24-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: N-((1S)-1-((1R)-2-(((1R,2R,4'S)-6'-(2,2-dimethylpropyl)-2-hydroxy-3',4'-dihydrospiro[cyclobutane-1,2'-pyrano[2,3-b]pyridin]-4'-yl)amino)-1-hydroxyethyl)-3-buten-1-yl)acetamide
• 英文别名: N-[(2R,3S)-1-[[(2R,2'R,4S)-6-(2,2-dimethylpropyl)-2'-hydroxyspiro[3,4-dihydropyrano[2,3-b]pyridine-2,1'-cyclobutane]-4-yl]amino]-2-hydroxyhex-5-en-3-yl]acetamide
• CAS: 1091623-24-3
• 化学式: C₂₄H₃₇N₃O₄
• 分子量: 431.575
• InChiKey: CMENVYWOGSGMDO-RSBOXOOMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• SUBSTITUTED HYDROXYETHYL AMINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE
  申请人：Amgen Inc.

  公开号：EP2167471B1

  公开（公告）日：2013-10-16
• DEUTERATED COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS
  申请人：MacCoss Malcolm

  公开号：US20110286969A1

  公开（公告）日：2011-11-24

  The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as wet! as methods of using them to treat disorders associated with the HCV protease An illustrative inventsve compound is shown below: Formula (I).