cis-2-Chlor-hepta-1,3-dien | 78422-94-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 乙烯基卤化物
• 英文名称: cis-2-Chlor-hepta-1,3-dien
• 英文别名: (3Z)-2-chlorohepta-1,3-diene
• CAS: 78422-94-3
• 化学式: C₇H₁₁Cl
• 分子量: 130.617
• InChiKey: FIKACSTWPZCXEY-WAYWQWQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

文献信息

• Hormone receptor modulators for treating metabolic conditions and disorders
  申请人：ARDELYX, INC.

  公开号：US10793568B2

  公开（公告）日：2020-10-06

  The invention relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): (I), wherein L1, A, X1, X2, R1, R2, and R3 are described herein.

  本发明涉及用于治疗自身免疫性疾病、肝脏疾病、肠道疾病、肾脏疾病、癌症和其他 FXR 起作用的疾病的 FXR 激活剂，其具有式 (I)：(I)，其中 L1、A、X1、X2、R1、R2 和 R3 如本文所述。
• Isoxazolyl-carbonyloxy azabicyclo[3.2.1]octanyl compounds as FXR activators
  申请人：ARDELYX, INC.

  公开号：US11091482B2

  公开（公告）日：2021-08-17

  The disclosure relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L1, L2, A, B, R1, R2, R3, and R4 are described herein.

  本公开涉及用于治疗自身免疫性疾病、肝脏疾病、肠道疾病、肾脏疾病、癌症和其他 FXR 起作用的疾病的 FXR 激活剂，其具有式（I）：其中 L1、L2、A、B、R1、R2、R3 和 R4 在本文中描述。
• HORMONE RECEPTOR MODULATORS FOR TREATING METABOLIC CONDITIONS AND DISORDERS
  申请人：Ardelyx, Inc.

  公开号：EP3504205B1

  公开（公告）日：2021-08-04
• ISOXAZOLYL-CARBONYLOXY AZABICYCLO[3.2.1]OCTANYL COMPOUNDS AS FXR ACTIVATORS
  申请人：ARDELYX, INC.

  公开号：US20190308973A1

  公开（公告）日：2019-10-10

  The disclosure relates to activators of FXR useful in the treatment of autoimmune disorders, liver disease, intestinal disease, kidney disease, cancer, and other diseases in which FXR plays a role, having the Formula (I): wherein L 1 , L 2 , A, B, R 1 , R 2 , R 3 , and R 4 are described herein.