tert-butyl N-[(2-methylpropan-2-yl)oxycarbonylamino]-N-(1-pyrrolidin-1-yl-1-sulfanylidenedecan-2-yl)carbamate | 140869-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tert-butyl N-[(2-methylpropan-2-yl)oxycarbonylamino]-N-(1-pyrrolidin-1-yl-1-sulfanylidenedecan-2-yl)carbamate
• CAS: 140869-69-8
• 化学式: C₂₄H₄₅N₃O₄S
• 分子量: 471.705
• InChiKey: IEVXMXNVZGDQQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  32
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[(2-methylpropan-2-yl)oxycarbonylamino]-N-(1-pyrrolidin-1-yl-1-sulfanylidenedecan-2-yl)carbamate 在 sodium hydroxide 、 三氟乙酸 作用下， 生成 2-Hydrazinyl-1-pyrrolidin-1-yldecane-1-thione
  参考文献：
  名称：

  Mono S-trimethylsilyl ketene dithioacetals as versatile tools for the synthesis of α-hydrazinodithioesters. A novel access to endothiopeptides.

  摘要：

  Mono-S-trimethylsilylketene dithioacetals have been prepared from dithioesters by the action of trimethylsilyl iodide formed in situ. They were reacted easily with dialkylazodicarboxylates to give good yields of alpha-hydrazinodithioesters. The latter were transformed into thioamides or endothiodipeptides by aminolysis either with an amine or an amino acid.

  DOI：

  10.1016/s0040-4039(00)91580-6
• 作为产物：
  描述：

  Silane, trimethyl[[1-(methylthio)-1-decenyl]thio]-, (E)- 在 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 tert-butyl N-[(2-methylpropan-2-yl)oxycarbonylamino]-N-(1-pyrrolidin-1-yl-1-sulfanylidenedecan-2-yl)carbamate
  参考文献：
  名称：

  Mono S-trimethylsilyl ketene dithioacetals as versatile tools for the synthesis of α-hydrazinodithioesters. A novel access to endothiopeptides.

  摘要：

  Mono-S-trimethylsilylketene dithioacetals have been prepared from dithioesters by the action of trimethylsilyl iodide formed in situ. They were reacted easily with dialkylazodicarboxylates to give good yields of alpha-hydrazinodithioesters. The latter were transformed into thioamides or endothiodipeptides by aminolysis either with an amine or an amino acid.

  DOI：

  10.1016/s0040-4039(00)91580-6