3-Benzyl-1,2-bis(methoxyhexaethylene glycol)glycerol | 1258000-13-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油脂
• 英文名称: 3-Benzyl-1,2-bis(methoxyhexaethylene glycol)glycerol
• 英文别名: 2,3-Bis[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propoxymethylbenzene
• CAS: 1258000-13-3
• 化学式: C₃₆H₆₆O₁₅
• 分子量: 738.911
• InChiKey: ZAEMOCZHBBBFOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  51
• 可旋转键数：
  43
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  138
• 氢给体数：
  0
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  3-Benzyl-1,2-bis(methoxyhexaethylene glycol)glycerol 在 钯 溶剂黄146 作用下， 以 正己烷 为溶剂， 以98%的产率得到3-hydroxyl-1,2-bis(methoxyhexaethylene glycol)glycerol
  参考文献：
  名称：

  HIGHLY MONODISPERSE BRANCHED PEG-LIPID CONJUGATES

  摘要：

  本文揭示了(PEG)-脂质共轭物及其制备方法。制备方法可能涉及将小的PEG寡聚体逐步添加到甘油骨架中，直到达到所需的链长。合成产物可能具有高度单分散性。所得的聚合物可能包括分支的聚乙二醇(PEG)-脂质共轭物。本公开可能提供多种优点，如简化合成、高产率和低起始材料成本。本合成方法可能适用于制备各种共轭物，如具有类甘油中心骨架的PEG脂质共轭物，其与两个或更多单分散PEG链和脂质共价连接，并包含一系列由脂肪酸或胆汁酸制成的二酯。

  公开号：

  US20120232169A1

文献信息

• PURE PEG-LIPID CONJUGATES
  申请人：Wu, Nian

  公开号：EP2437756A2

  公开（公告）日：2012-04-11
• Pure PEG-lipid conjugates
  申请人：Wu Nian

  公开号：US20110040113A1

  公开（公告）日：2011-02-17

  Syntheses of polyethyleneglycol (PEG)-lipid conjugates are disclosed. Such syntheses involve stepwise addition of small PEG oligomers to a glycerol backbone until the desired chain size is attained. Polymers resulting from the syntheses are highly monodisperse. The present invention provides several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method is suitable for preparing a wide range of conjugates. In another aspect, the invention comprises PEG lipid conjugates having a glycerol backbone covalently attached to one or two monodisperse PEG chains and one or two lipids. These conjugates are especially useful for pharmaceutical formulations.
• [EN] PURE PEG-LIPID CONJUGATES<br/>[FR] CONJUGUÉS PEG-LIPIDES PURS
  申请人：WU NIAN

  公开号：WO2010141069A2

  公开（公告）日：2010-12-09

  Syntheses of polyethyleneglycol (PEG)-lipid conjugates are disclosed. Such syntheses involve stepwise addition of small PEG oligomers to a glycerol backbone until the desired chain size is attained. Polymers resulting from the syntheses are highly monodisperse. The present invention provides several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method is suitable for preparing a wide range of conjugates. In another aspect, the invention comprises PEG lipid conjugates having a glycerol backbone covalently attached to one or two monodisperse PEG chains and one or two lipids. These conjugates are especially useful for pharmaceutical formulations.