4,7,10,13,16,41,44,47,50,53-decaoxa-28,29-dithiahexapentaconta-1,55-diyne | 1338950-91-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 有机二硫化物
• 英文名称: 4,7,10,13,16,41,44,47,50,53-decaoxa-28,29-dithiahexapentaconta-1,55-diyne
• CAS: 1338950-91-6
• 化学式: C₄₄H₈₂O₁₀S₂
• 分子量: 835.261
• InChiKey: WARAVXGJLPKHBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.82
• 重原子数：
  56.0
• 可旋转键数：
  51.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  92.3
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  三缩四乙二醇 在 盐酸 、 氨甲基膦酸 、 sodium hydride 、 potassium carbonate 、 copper(II) sulfate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 为溶剂， 反应 1.0h， 生成 4,7,10,13,16,41,44,47,50,53-decaoxa-28,29-dithiahexapentaconta-1,55-diyne
  参考文献：
  名称：

  On-Demand Electrochemical Activation of the Click Reaction on Self-Assembled Monolayers on Gold Presenting Masked Acetylene Groups

  摘要：

  We report on a new surface modification method for grafting a "dynamic" property for on-demand activation of the click reaction. Our approach utilizes the acetylene group masked with dicobalt hexacarbonyl, Co-2-(CO)(6), which is not reactive toward the click reaction. Electrochemical treatment reveals the acetylene group on the selected region, which is then used as a chemical handle for surface functionalization via the click reaction with an azide-containing molecule. Electrochemical and chemical conversions on the surface were verified by cyclic voltammetry, X-ray photoelectron spectroscopy, and fluorescence spectroscopy. We have demonstrated immobilization of an azide-modified RGD peptide and promotion of cell adhesion/migration to the region of electrochemical induction.

  DOI：

  10.1021/ja2083587