5-chloro-N2-(3-chloro-4-methoxy-5-methylphenyl)-N4-[(4-(dimethylamino)sulfonylamino)methylphenyl]-2,4-pyrimidinediamine | 1065082-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-chloro-N2-(3-chloro-4-methoxy-5-methylphenyl)-N4-[(4-(dimethylamino)sulfonylamino)methylphenyl]-2,4-pyrimidinediamine
• 英文别名: 5-Chloro-2-(3-chloro-4-methoxy-5-methylanilino)-4-[4-[(dimethylsulfamoylamino)methyl]anilino]pyrimidine
• CAS: 1065082-27-0
• 化学式: C₂₁H₂₄Cl₂N₆O₃S
• 分子量: 511.432
• InChiKey: IKMGBRFNZPIVJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  117
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY
  申请人：Atuegbu Andy

  公开号：US20080279867A1

  公开（公告）日：2008-11-13

  The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.

  本发明涵盖具有I式的化合物，以及使用这些化合物在调节JAK途径或抑制JAK激酶，特别是JAK3，在治疗治疗上具有治疗用途的条件中的组合物和方法。
• METALLOCENE SUPPORTED CATALYST COMPOSITION AND A PROCESS FOR THE PREPARATION OF POLYOLEFIN USING THE SAME
  申请人：SK Energy Co., Ltd.

  公开号：EP2258731A2

  公开（公告）日：2010-12-08

  The invention relates to a metallocene supported catalyst composition and a process for the preparation of polyolefin using the same. A metallocene supported catalyst composition according to the invention is prepared by bringing a compound of a group IV transition metal into contact with an inorganic or organic porous carrier treated with an ionic compound. Advantages of a metallocene supported catalyst composition of the invention include an increase in the catalyst activity during polymerization of slurry and an olefin compound in the vapor phase even at a low content of metallocene metal components within the carrier, and an improvement in solving process problems such as fouling, sheeting, plugging or the like.

  本发明涉及一种茂金属载体催化剂组合物和使用该组合物制备聚烯烃的工艺。根据本发明的茂金属载体催化剂组合物是通过使第 IV 族过渡金属化合物与用离子化合物处理过的无机或有机多孔载体接触而制备的。本发明的茂金属载体催化剂组合物的优点包括：即使载体中的茂金属成分含量较低，在气相浆料和烯烃化合物聚合过程中，催化剂活性也会提高；在解决诸如结垢、成片、堵塞等工艺问题方面也会有所改进。
• Metallocene Supported Catalyst Composition and a Process for the Preparation of Polyolefin Using the Same
  申请人：Han Seungyeol

  公开号：US20110105705A1

  公开（公告）日：2011-05-05

  The invention relates to a metallocene supported catalyst composition and a process for the preparation of polyolefin using the same. A metallocene supported catalyst composition according to the invention is prepared by bringing a compound of a group IV transition metal into contact with an inorganic or organic porous carrier treated with an ionic compound. Advantages of a metallocene supported catalyst composition of the invention include an increase in the catalyst activity during polymerization of slurry and an olefin compound in the vapor phase even at a low content of metallocene metal components within the carrier, and an improvement in solving process problems such as fouling, sheeting, plugging or the like.
• US7947698B2
  申请人：——

  公开号：US7947698B2

  公开（公告）日：2011-05-24
• US8304422B2
  申请人：——

  公开号：US8304422B2

  公开（公告）日：2012-11-06