Boc-His(τ-MBom)-OMe | 1350698-32-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-His(τ-MBom)-OMe
• CAS: 1350698-32-6
• 化学式: C₂₁H₂₉N₃O₆
• 分子量: 419.478
• InChiKey: BGHBJSPKOSMOLF-SFHVURJKSA-N

反应信息

• 作为反应物：
  描述：

  Boc-His(τ-MBom)-OMe 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  4-Methoxybenzyloxymethyl group as an Nπ-protecting group for histidine to eliminate side-chain-induced racemization in the Fmoc strategy

  摘要：

  The 4-methoxybenzyloxymethyl (MBom) group was introduced at the Nit-position of histidine, and its utility was examined under the conditions for peptide synthesis by Fmoc strategy. The N-pi-MBom group proved to prevent the risk of racemization during incorporation of the His residue and to possess all of the chemical properties required for Fmoc chemistry. The side reaction associated with formaldehyde generated from the N-pi-MBom group upon acidolysis could be effectively prevented by performing the standard TFA treatment in the presence of methoxyamine center dot hydrochloride (MeONH2 center dot HCl). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.065