2(RS)-acetylamino-3-cyclohexyl-N-{1-[(4-hydroxyphenylsulfamoyl)methyl]-3-phenyl-propyl}-propionamide | 503314-71-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2(RS)-acetylamino-3-cyclohexyl-N-{1-[(4-hydroxyphenylsulfamoyl)methyl]-3-phenyl-propyl}-propionamide
• 英文别名: 2-acetamido-3-cyclohexyl-N-[1-[(4-hydroxyphenyl)sulfamoyl]-4-phenylbutan-2-yl]propanamide
• CAS: 503314-71-4
• 化学式: C₂₇H₃₇N₃O₅S
• 分子量: 515.674
• InChiKey: YPTFQQGOVMRFQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Sulfonamide compounds as protease inhibitors
  申请人：——

  公开号：US20030158231A1

  公开（公告）日：2003-08-21

  The present invention relates to novel cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.

  本发明涉及新型半胱氨酸蛋白酶抑制剂；其药用盐和N-氧化物；它们作为治疗剂的用途以及其制备方法。
• Fluorinated zwitterionic cocatalyst activators for olefin polymerization
  申请人：——

  公开号：US20040110631A1

  公开（公告）日：2004-06-10

  Zwitterionic compositions of matter comprising cations [Ct] + and anions connected together with substantially rigid fluorinated linking groups are described. These zwitterionic compositions serve as cocatalysts. They activate olefin polymerization catalysts, and can dissolve in aliphatic solvents. Synthesis and polymerization are illustrated.

  由阳离子[Ct&rsqb； &plus； 和阴离子，并用基本刚性的氟化连接基团连接在一起。这些齐聚物可用作催化剂。它们能激活烯烃聚合催化剂，并能溶解在脂肪族溶剂中。图解说明了合成和聚合过程。
• US6919291B2
  申请人：——

  公开号：US6919291B2

  公开（公告）日：2005-07-19
• US6900237B2
  申请人：——

  公开号：US6900237B2

  公开（公告）日：2005-05-31
• [EN] SULFONAMIDE COMPOUNDS AS PROTEASE INHIBITORS<br/>[FR] COMPOSES SULFONAMIDE EN TANT QU'INHIBITEURS DE PROTEASE
  申请人：AXYS PHARM INC

  公开号：WO2003024923A1

  公开（公告）日：2003-03-27

  The present invention relates to cysteine protease inhibitors of the general formula I, the pharmaceutically acceptable salts and N-oxides thereof; their uses as therapeutic agents and the methods of their making.