1-ethyl-2-{bis[2-(2-pyridyl)ethyl]selenophosphorylhydroxymethyl}imidazole | 1185525-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-ethyl-2-{bis[2-(2-pyridyl)ethyl]selenophosphorylhydroxymethyl}imidazole
• 英文别名: bis(2-pyridin-2-ylethyl)phosphinoselenoyl-(1-ethylimidazol-2-yl)methanol
• CAS: 1185525-39-6
• 化学式: C₂₀H₂₅N₄OPSe
• 分子量: 447.378
• InChiKey: JQEMASHEIYBKKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.27
• 重原子数：
  27
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-ethyl-2-{bis[2-(2-pyridyl)ethyl]selenophosphorylhydroxymethyl}imidazole 生成
  参考文献：
  名称：

  Reaction of imidazole series aldeydes with bis[2-(2-pyridyl)ethyl]-phosphine chalcogenides: Synthesis of polyfunctional heterocyclic systems

  摘要：

  The nucleophilic addition of bis[2-(2-pyridyl)ethyl]phosphine sulfide and bis[2-(2-pyridyl)-ethyl]phosphine selenide to 2-formyl-1-organylimidazoles and benzimidazoles occurs efficiently without catalysis at room temperature to give functionalized heterocyclic compounds containing imidazole, benzimidazole, and pyridine rings and also chalcogenophosphoryl and hydroxyl groups.

  DOI：

  10.1007/s10593-009-0196-8
• 作为产物：
  描述：

  bis[2-(2-pyridyl)ethyl]phosphine selenide 、 1-乙基-1H-咪唑-2-甲醛 以 四氢呋喃 为溶剂， 反应 3.0h， 以79%的产率得到1-ethyl-2-{bis[2-(2-pyridyl)ethyl]selenophosphorylhydroxymethyl}imidazole
  参考文献：
  名称：

  Reaction of imidazole series aldeydes with bis[2-(2-pyridyl)ethyl]-phosphine chalcogenides: Synthesis of polyfunctional heterocyclic systems

  摘要：

  The nucleophilic addition of bis[2-(2-pyridyl)ethyl]phosphine sulfide and bis[2-(2-pyridyl)-ethyl]phosphine selenide to 2-formyl-1-organylimidazoles and benzimidazoles occurs efficiently without catalysis at room temperature to give functionalized heterocyclic compounds containing imidazole, benzimidazole, and pyridine rings and also chalcogenophosphoryl and hydroxyl groups.

  DOI：

  10.1007/s10593-009-0196-8