| 1355222-11-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1355222-11-5
• 化学式: C₂₆H₄₆N₂O₈
• 分子量: 514.66
• InChiKey: LPRUHPKHXDGUSQ-GOSISDBHSA-N

反应信息

• 作为反应物：
  描述：

  在 盐酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 1.0h， 以30%的产率得到2-[[(5R)-6-amino-5-hydroxyhexanoyl]-(carboxymethyl)amino]acetic acid
  参考文献：
  名称：

  Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy

  摘要：

  A series of (+)-negamycin 1 analogues were synthesized, and their readthrough-promoting activity was evaluated for nonsense mutations in Duchenne muscular dystrophy 3 (DMD). A structure activity relationship study indicated that 11b was the most potent drug 0 candidate. Immunohistochemical analyses suggested that treatment with 11b restored dystrophin expression in mdx mice, a DMD mouse model. Furthermore, lib decreased serum creatine kinase (CK) levels, an indicator of muscle fiber destruction. Most importantly, 11b demonstrated lower toxicity than 1, and thus, it could be a useful candidate for long-term treatment of DMD.

  DOI：

  10.1021/ml200245t