Lysine Nz-Carboxylic Acid | 45101-60-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Lysine Nz-Carboxylic Acid
• 英文别名: (2S)-2-amino-6-(carboxyamino)hexanoic acid
• CAS: 45101-60-8
• 化学式: C₇H₁₄N₂O₄
• 分子量: 190.2
• InChiKey: PWIKLEYMFKCERQ-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Automated identification of peptides
  申请人：——

  公开号：US20020102610A1

  公开（公告）日：2002-08-01

  A fully automated, user-independent method is described for computer-mediated interpretation of data derived by mass spectrometry of an experimental peptide to identify and characterize a corresponding peptide sequence in a peptide database. The method identifies the corresponding sequence if it is present in the database, without the need for a skilled observer to choose from amongst a list of possible matches. By using an automated back-read process, the present method can uniquely identify a corresponding peptide sequence in a database based on a single matching peptide sequence. The method also permits mapping of mass spectral data to sequences in peptide or nucleotide databases for unambiguous identification of exons; determining a correct reading frame; identifying artefacts and errors in sequences; identifying mutations and polymorphisms; identifying post-translational modifications; and identifying exon-intron boundaries.

  本文描述了一种完全自动化、不依赖用户的方法，用于通过质谱技术获得的实验性肽段数据的计算机介导解释，以识别和表征相应的肽段序列在肽段数据库中的对应关系。该方法可以在不需要熟练的观察者从可能匹配的列表中选择的情况下，识别出数据库中存在的相应序列。通过使用自动化的反向读取过程，本方法可以基于单个匹配的肽段序列，在数据库中唯一地识别相应的肽段序列。该方法还允许将质谱数据映射到肽或核苷酸数据库中的序列，以明确识别外显子；确定正确的阅读框架；识别序列中的工件和错误；识别突变和多态性；识别后翻译修饰；以及识别外显子-内含子边界。
• Amino Acid Derivatives
  申请人：MEDIMMUNE LIMITED

  公开号：US20160176811A1

  公开（公告）日：2016-06-23

  There are provided pyrrolysine analogues of the formulae (X), (I), (II), (V), (VI), (VII) and (VIII), in which the a, b, d, X, Y, Z, FG, R, R 1 , R 2 and R 3 are as defined in the claims, which are useful in bioconjugation processes and mutant proteins containing them.

  提供了公式（X），（I），（II），（V），（VI），（VII）和（VIII）的吡咯赖氨酸类似物，其中a，b，d，X，Y，Z，FG，R，R1，R2和R3如权利要求所定义，在生物共轭过程和含有它们的突变蛋白质中有用。
• Detection of peptides
  申请人：Millipore Corporation

  公开号：EP2128619A1

  公开（公告）日：2009-12-02

  A method for determining the presence of one or more proteins of interest in a sample, which method comprises the step of: c) submitting the sample to conditions that allow fragmentation of the protein into target peptide fragments; and d) contacting the target peptide fragments with an array of capture agents immobilized on a solid support, the capture agents comprising those that recognize a target protein fragment; whereby the binding of the target peptide fragments with the capture agents is indicative of the presence of the protein(s) in the sample. A device comprising such an array, and its production, are also described.

  一种确定样品中是否存在一种或多种相关蛋白质的方法，该方法包括以下步骤：c) 将样品置于可将蛋白质破碎成目标肽片段的条件下；d) 将目标肽片段与固定在固体支持物上的捕获剂阵列接触，捕获剂包括可识别目标蛋白质片段的捕获剂；目标肽片段与捕获剂的结合表明样品中存在蛋白质。此外，还介绍了一种包含这种阵列的装置及其生产方法。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• Compositions and methods related to inhibition of respiratory syncytial virus entry
  申请人：Navigen, Inc.

  公开号：US10765754B2

  公开（公告）日：2020-09-08

  Disclosed herein are compositions and methods for inhibiting respiratory syncytial virus (RSV) entry into a host cell. Also provided herein are methods of identifying a peptide that interacts with the N-trimer of RSV F protein.

  本文公开了抑制呼吸道合胞病毒（RSV）进入宿主细胞的组合物和方法。本文还提供了鉴定与 RSV F 蛋白的 N 三聚体相互作用的多肽的方法。