名称:
Solid phase synthesis of a molecular library of pyrimidines, pyrazoles, and isoxazoles with biological potential
摘要:
A small molecular library of 40 Pyrimidine, pyrazole, and isoxazole derivatives, bearing structural features for a promising binding of therapeutically interesting enzymes, was designed and prepared. An efficient and straightforward solid phase synthesis was envisaged and carried out on a Rink amide resin. The assistance Of Microwave heating in any step reduced the reaction time, increased the reaction yields, and allowed an easy work-up and purification of the targeted compounds. (C) 2010 Elsevier Ltd. All rights reserved.