DOTAP | 477274-39-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: DOTAP
• 英文别名: 2,3-Di(octadec-9-enoyloxy)propyl-trimethylazanium;chloride
• CAS: 477274-39-8
• 化学式: C₄₂H₈₀NO₄*Cl
• 分子量: 698.554
• InChiKey: KSXTUUUQYQYKCR-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  9.23
• 重原子数：
  48
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  DOTAP 、 双(三氟甲基磺酰基)酰亚胺钾 以 水 为溶剂， 生成
  参考文献：
  名称：

  Structure-based tuning of Tm in lipid-like ionic liquids. Insights from Tf2N− salts of gene transfection agents

  摘要：

  研究表明，带有两个类脂脂族尾部的阳离子的离子液体的 Tm 值可以很低，而且可以通过添加、删除或组合双极模块和侧链双键来调高或调低 Tm 值。

  DOI：

  10.1039/c2cc33609j
• 作为产物：
  描述：

  甲醇 、 DODAP 在 氯甲烷磺酰氟 、 sodium carbonate 、 盐酸 作用下， 以 氯苯 为溶剂， 以76 %的产率得到DOTAP
  参考文献：
  名称：

  CN116003271

  摘要：

  公开号：

文献信息

• Pyridinium cationic lipids as gene transfer agents
  申请人：Balaban T. Alexandru

  公开号：US20050196863A1

  公开（公告）日：2005-09-08

  Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents.

  披萨是一种美味的食物，通常由面团、番茄酱、奶酪和各种配料制成。
• Concentrated, stable, preferably clear, fabric softening composition
  申请人：Trinh Toan

  公开号：US20060058216A1

  公开（公告）日：2006-03-16

  Principal solvents, especially mono-ol and diol principal solvents, having a ClogP of from about 0.15 to about 0.64, preferably from about 0.25 to about 0.62, and more preferably from about 0.40 to about 0.60, are disclosed that have the ability to make clear aqueous fabric softener compositions containing relatively high concentrations of fabric softener actives having ester linkages in their long, hydrophobic chains. The fabric softener actives are either unsaturated, or have intermediate length chains (˜C 12-14 ) and the said principal solvents are used at levels of less than about 40%. Other solvents may be present. Some of the said principal solvents are novel compounds and/or novel mixtures. Premixes of the fabric softening actives, the principal solvents, and, optionally, other solvents are useful in the preparation of complete formulations by obviating/limiting the need for heating.

  本发明揭示了主要溶剂，特别是具有ClogP约为0.15至约0.64，优选为约0.25至约0.62，更优选为约0.40至约0.60的单醇和双醇主要溶剂，具有制备含有长链疏水基中酯键的相对高浓度织物柔顺剂活性成分的清澈水性织物柔顺剂组合物的能力。织物柔顺剂活性成分可以是不饱和的，也可以具有中等长度的链（约C12-14），所述主要溶剂的使用水平小于约40％。其他溶剂可以存在。其中一些主要溶剂是新化合物和/或新混合物。织物柔顺剂活性成分、主要溶剂和可选的其他溶剂的预混物在制备完整配方时是有用的，因为它们可以避免/限制加热的需要。
• BIOMEDICAL MATERIALS FOR TISSUE ENGINEERING
  申请人：TSAI Pei-Yi

  公开号：US20130059382A1

  公开（公告）日：2013-03-07

  In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues.

  在本公开的实施例中，提供了一种生物医学材料。生物医学材料包括具有表面的生物相容性材料和分布在生物相容性材料表面上的载体，其中生物相容性材料和载体都没有电荷，它们中的一个具有电荷或两者具有不同电荷的电荷。该生物医学材料用于牙科、骨科、伤口愈合或医学美容，并应用于各种软组织和硬组织的修复和再生。
• METHOD FOR TISSUE ENGINEERING
  申请人：Industrial Technology Research Institute

  公开号：US20140220085A1

  公开（公告）日：2014-08-07

  In an embodiment of the disclosure, a biomedical material is provided. The biomedical material includes a biocompatible material having a surface and a carrier distributed over the surface of the biocompatible material, wherein both of the biocompatible material and the carrier have no charges, one of them has charges or both of them have charges with different electricity. The biomedical material is utilized for dentistry, orthopedics, wound healing or medical beauty and applied in the repair and regeneration of various soft and hard tissues.

  在公开实施例中，提供了一种生物医学材料。该生物医学材料包括具有表面的生物相容性材料和分布在生物相容性材料表面上的载体，其中生物相容性材料和载体都没有电荷，其中一个具有电荷，或者两者具有不同电荷。该生物医学材料用于牙科，骨科，伤口愈合或医疗美容，并应用于各种软组织和硬组织的修复和再生。
• Carrier: DNA complexes containing DNA encoding anti-angiogenic peptides and their use in gene therapy
  申请人：Mixson, Archibald James

  公开号：EP0921193A1

  公开（公告）日：1999-06-09

  Carrier complexes comprising DNA encoding an anti-angiogenic gene or peptide and optionally a further DNA encoding a tumor suppressor protein are described. When administered to a subject bearing a tumor, the complexes can inhibit growth of the tumor.

  所述载体复合物包括编码抗血管生成基因或肽的 DNA 和另一种编码肿瘤抑制蛋白的 DNA。当给患有肿瘤的受试者施用时，这些复合物可抑制肿瘤的生长。