(S)-1-(phenylseleno)-2-octanol | 834882-70-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-(phenylseleno)-2-octanol
• 英文别名: (2S)-1-(Phenylselanyl)octan-2-OL；(2S)-1-phenylselanyloctan-2-ol
• CAS: 834882-70-1
• 化学式: C₁₄H₂₂OSe
• 分子量: 285.288
• InChiKey: SBCFFISWKUZABD-ZDUSSCGKSA-N

物化性质

• 沸点：
  364.7±34.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.77
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙酸乙烯酯 、 1-(phenylselanyl)octan-2-ol 在 immobilized Novozym 435(R) Candida antarctica lipase-B 作用下， 以 正己烷 为溶剂， 生成 (R)-1-(phenylseleno)-2-octanol 、 (S)-1-(phenylseleno)-2-octanol 、 (S)-O-acetyl-1-(phenylseleno)-2-octanol 、 (R)-O-acetyl-1-(phenylseleno)-2-octanol
  参考文献：
  名称：

  Enzymatic resolution of (RS)-β-hydroxy selenides in organic media

  摘要：

  Kinetic resolutions of a number of beta-hydroxy selenides promoted by enzymes were performed using PPL (free Porcine pancreatic lipase), PSL (Amano PS-free Pseudomonas sp. lipase) and CALB (NOVOZYM 435(R)-immobilized Candida Antarctica lipase type B) with (RS)-1-phenylselanyl-propan-2-ol. CALB gave the best results and provided both (R)- and (S)-enantiomers in high enantiomeric purity. A comparative study of the effect of temperature, solvent, enzyme immobilization and the structure of the substrates on the resolution is presented. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.11.007

文献信息

• Enzymatic resolution of (RS)-β-hydroxy selenides in organic media
  作者：Carlos E. Costa、Giuliano C. Clososki、Henrique B. Barchesi、Sandra P. Zanotto、M. Graça Nascimento、João V. Comasseto

  DOI：10.1016/j.tetasy.2004.11.007

  日期：2004.12

  Kinetic resolutions of a number of beta-hydroxy selenides promoted by enzymes were performed using PPL (free Porcine pancreatic lipase), PSL (Amano PS-free Pseudomonas sp. lipase) and CALB (NOVOZYM 435(R)-immobilized Candida Antarctica lipase type B) with (RS)-1-phenylselanyl-propan-2-ol. CALB gave the best results and provided both (R)- and (S)-enantiomers in high enantiomeric purity. A comparative study of the effect of temperature, solvent, enzyme immobilization and the structure of the substrates on the resolution is presented. (C) 2004 Elsevier Ltd. All rights reserved.