2'-doxy-2'-β-fluoro-4'-azido-3'-O-benzoyl-5'-O-(m-chlorobenzoyl)uridine | 1360459-46-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2'-doxy-2'-β-fluoro-4'-azido-3'-O-benzoyl-5'-O-(m-chlorobenzoyl)uridine
• 英文别名: 4-amino-1-[(2R,3S,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(4-hydroxybut-1-ynyl)pyrimidin-2-one
• CAS: 1360459-46-6
• 化学式: C₁₃H₁₅FN₆O₅
• 分子量: 354.298
• InChiKey: WUXYJUIMVQQRFI-FIQUKUQUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• PYRIMIDINE NUCLEOSIDE DERIVATIVES, SYNTHESIS METHODS AND USES THEREOF FOR PREPARING ANTI-TUMOR AND ANTI-VIRUS MEDICAMENTS
  申请人：Chang Junbiao

  公开号：US20130303747A1

  公开（公告）日：2013-11-14

  The present invention relates to the field of pharmacochemistry. Disclosed are fluorinated and azido-substituted pyrimidine nucleoside derivatives, and preparation methods and uses thereof. The structural formula is as shown (I). These compounds can be used for preparing medicaments for treating diseases such as tumors and viral infections, and can be used separately or in combination with other medicaments. The compounds also have effective activity against diseases such as tumors and viral infections, while having few side effects, and thus have potential application value.

  本发明涉及药物化学领域。公开了氟代和偶氮基取代的嘧啶核苷衍生物，以及其制备方法和用途。结构式如所示（I）。这些化合物可用于制备治疗肿瘤和病毒感染等疾病的药物，可单独使用或与其他药物结合使用。这些化合物还对肿瘤和病毒感染等疾病具有有效活性，副作用较少，因此具有潜在的应用价值。
• US9422321B2
  申请人：——

  公开号：US9422321B2

  公开（公告）日：2016-08-23